CHRM3 protein, human

Known as: M3 Muscarinic Receptor, Muscarinic Acetylcholine Receptor M3, Cholinergic Receptor, Muscarinic 3 
Muscarinic acetylcholine receptor M3 (590 aa, ~66 kDa) is encoded by the human CHRM3 gene. This protein plays a role in both acetylcholine binding… (More)
National Institutes of Health

Related topics

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13 relations
CHRM3 geneG Protein-Coupled Receptor GenesG Protein-Coupled Receptor SignalingIntegral Membrane Proteins
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Broader (1)

Muscarinic Acetylcholine Receptor

Papers overview

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2008
2008
Ligation of Toll-like receptor 3 differentially regulates M2 and M3 muscarinic receptor expression and function in human airway smooth muscle cells.
BACKGROUND Viral infection causes asthma exacerbations and airway hyperreactivity. Toll-like receptor 3 (TLR3) recognizes double… (More)
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2005
2005
Rapacuronium preferentially antagonizes the function of M2 versus M3 muscarinic receptors in guinea pig airway smooth muscle.
BACKGROUND Rapacuronium, a nondepolarizing muscle relaxant that was proposed as a replacement for succinylcholine for rapid… (More)
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Highly Cited
1999
Highly Cited
1999
Identification and molecular characterization of m3 muscarinic receptor dimers.
Several studies suggest, but do not prove directly, that muscarinic receptors may be able to form dimeric or oligomeric arrays… (More)
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Highly Cited
1997
Highly Cited
1997
Chemotaxis in a lymphocyte cell line transfected with C-C chemokine receptor 2B: evidence that directed migration is mediated by betagamma dimers released by activation of Galphai-coupled receptors.
Chemotaxis is mediated by activation of seven-transmembrane domain, G protein-coupled receptors, but the signal transduction… (More)
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1995
1995
Plasma membrane localization and functional rescue of truncated forms of a G protein-coupled receptor.
To test the hypothesis that G protein-coupled receptors consist of multiple autonomous folding domains, the rat m3 muscarinic… (More)
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1995
1995
Mapping of single amino acid residues required for selective activation of Gq/11 by the m3 muscarinic acetylcholine receptor.
Each G protein-coupled receptor can interact only with a limited number of the many structurally similar G proteins expressed… (More)
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1993
1993
Distinct kinetic binding properties of N-[3H]-methylscopolamine afford differential labeling and localization of M1, M2, and M3 muscarinic receptor subtypes in primate brain.
Three classes of muscarinic receptors in mammalian brain have been postulated on the basis of equilibrium and kinetic binding… (More)
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1992
1992
Muscarinic receptor-operated Ca2+ influx in transfected fibroblast cells is independent of inositol phosphates and release of intracellular Ca2+.
Receptor-mediated changes in cytoplasmic calcium concentrations occur either through release from intracellular calcium stores or… (More)
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1991
1991
Development of an antiserum against m3 muscarinic receptors: distribution of m3 receptors in rat tissues and clonal cell lines.
A synthetic oligopeptide (QCDKRKRRKQQYQQRQSV) corresponding to a carboxyl-terminal sequence of the rat m3 receptor (amino acids… (More)
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1991
1991
Site-directed mutagenesis of the m3 muscarinic receptor: identification of a series of threonine and tyrosine residues involved in agonist but not antagonist binding.
The hydrophobic core of all muscarinic receptors contains several conserved serine, threonine and tyrosine residues, most of… (More)
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