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Vasopressin-dependent trafficking of AQP2 in the renal collecting duct is crucial for the regulation of water homeostasis. This… Expand Integration and down-regulation of cell growth and differentiation signals rely on plasma membrane receptor endocytosis and… Expand ESCRTs work in two very different ways The so-called ESCRT proteins are involved in the budding of vesicles into the lumen of… Expand Analysis of mutant plants points to a direct role for CHMP1 in plastid autophagy, demonstrating a connection between the ESCRT… Expand The MITD1 is an largely uncharacterized MIT domain–containing protein. This protein localizes to the midbody, with its… Expand Some intracellular proteins involved in the endosomal sorting complex required for transport (ESCRT) system have microtubule… Expand The endosomal sorting complex required for transport (ESCRT) machinery, including ESCRT-III, localizes to the midbody and… Expand The AAA+ ATPase VPS4 plays an essential role in multivesicular body biogenesis and is thought to act by disassembling ESCRT-III… Expand The “class E” vacuolar protein sorting (VPS) pathway mediates sorting of ubiquitinated cargo into the forming vesicles of the… Expand Pure hereditary spastic paraplegia is characterized by length-dependent degeneration of the distal ends of long axons. Mutations… Expand