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CHIR-265
A novel, orally active, small molecule with potential antineoplastic activity.CHIR-265 binds and inhibits Raf kinases, which may result in a…
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National Institutes of Health
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RAF265
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2006
2006
CHIR-265 is a potent selective inhibitor of c-Raf/B-Raf/mutB-Raf that effectively inhibits proliferation and survival of cancer cell lines with Ras/Raf pathway mutations
P. Amiri
,
Aikawa Mina
,
+9 authors
Renhow Paul
2006
Corpus ID: 83660580
4855 The Ras/Raf/MEK/ERK signal transduction cascade is a very compelling pathway to disrupt in several cancer types because of…
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2006
2006
CHIR-265, a novel inhibitor that targets B-Raf and VEGFR, shows efficacy in a broad range of preclinical models
E. Venetsanakos
,
D. Stuart
,
+7 authors
B. Jallal
2006
Corpus ID: 70397101
4854 Activation of the Ras-Raf-MEK-ERK pathway plays an integral role in tumor cell proliferation and survival. Mutations in Ras…
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