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CGS 35066

Known as: 3-dibenzofuran-3-yl-2-(phosphonomethylamino)propionic acid, CGS-35066, CGS35066 
National Institutes of Health

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2 relations

Broader (2)

BenzofuransOrganophosphonates

Papers overview

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2013
2013
Soluble and Catalytically Active Endothelin Converting Enzyme-1 is Present in Cerebrospinal Fluid of Subarachnoid Hemorrhage Patients
Endothelin converting Enzyme-1 (ECE-1) is essential for the production of Endothelin-1 (ET-1), which is associated with vasospasm… 
2010
2010
Role of Protein Kinase C in Endothelin Converting Enzyme-1 trafficking and shedding from endothelial cells.
2007
2007
The peptidase inhibitor CGS‐26303 increases endothelin converting enzyme‐1 expression in endothelial cells through accumulation of big endothelin‐1
CGS‐26303 inhibits endothelin converting enzyme (ECE)‐1 more specifically than phosphoramidon. We have studied the effect of CGS… 
2006
2006
Enzymatic pathways involved in the generation of endothelin‐1(1–31) from exogenous big endothelin‐1 in the rabbit aorta
1 We investigated whether blood vessels contribute to the production of ET‐1(1–31) from exogenous big endothelin‐1 (BigET‐1) in… 
2006
2006
Prevention and Reversal of Vasospasm and Ultrastructural Changes in Basilar Artery by Continuous Infusion of CGS 35066 Following Subarachnoid Hemorrhage
Endothelin-1, a potent vasoconstrictive peptide, has been implicated in the pathogenesis of cerebral vasospasm following… 
2004
2004
Endothelin-converting enzyme inhibitors and their potential for cardiovascular and renal therapeutics
Inhibition of endothelin-converting enzyme (ECE) will reduce the levels of endothelin-1 (ET-1). A pathological effect for ECE/ET… 
2002
2002
Effects of benazepril, an angiotensin-converting enzyme inhibitor, combined with CGS 35066, a selective endothelin-converting enzyme inhibitor, on arterial blood pressure in normotensive and…
Continuous intra-arterial administration of a selective endothelin-converting enzyme (ECE) inhibitor CGS 35066 at a dose of 30 mg… 
2002
2002
Role of endothelin-converting enzyme, chymase and neutral endopeptidase in the processing of big ET-1, ET-1(1-21) and ET-1(1-31) in the trachea of allergic mice.
The present study examined the roles of endothelin-converting enzyme (ECE), neutral endopeptidase (NEP) and mast cell chymase as… 
2002
2002
Attenuation of SAH-induced cerebral vasospasm by a selective ECE inhibitor
CGS 26303, a dual inhibitor of endothelin-converting enzyme-1 (ECE-1) and neutral endopeptidase 24.11, was previously shown to… 
2000
2000
Design and synthesis of a potent and selective endothelin-converting enzyme inhibitor, CGS 35066.
CGS 26303 has previously been shown to inhibit human endothelin converting enzyme-1 (ECE-1) with an IC50 of 410 nM and to be… 
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