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CGP 74588

Known as: CGP-74588, CGP74588 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

PiperazinesPyrimidines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Single-nucleotide polymorphisms of ABCG 2 increase the efficacy of tyrosine kinase inhibitors in the K 562 chronic myeloid leukemia cell line
Objective: The tyrosine kinase inhibitors (TKIs) used in the treatment of chronic myeloid leukemia are substrates for the efflux… 
2013
2013
CYP 3 A activity influences imatinib response in patients with chronic myeloid leukemia : a pilot study on in vivo CYP 3 A activity
...................................................................................................................... 5 POPUL… 
2013
2013
Long-term Prospective Population PK Study in GIST Patients—Response
We thank Chatelut and colleagues for their interest in our prospective population pharmacokinetic analysis of imatinib exposure… 
2012
2012
Biliary Excretion of Imatinib and Its Active Metabolite CGP74588 During Severe Hepatic Dysfunction
1115 2012 52 1115-1120 I (STI571, Gleevec) was the first approved rationally designed inhibitor of tyrosine kinases and is… 
2011
2011
Optimization of the simultaneous determination of imatinib and its major metabolite, CGP74588, in human plasma by a rapid HPLC method using D-optimal experimental design.
Review
2010
Review
2010
Liver transplantation for metastasized extragastrointestinal stromal tumor: a case report and an overview of literature.
Highly Cited
2008
Highly Cited
2008
Influence of Enzyme-Inducing Antiepileptic Drugs on Trough Level of Imatinib in Glioblastoma Patients
Background: Imatinib mesylate is used in combination with hydroxyurea (HU) in ongoing clinical phase II studies in recurrent… 
2008
2008
ABC transporters and the accumulation of imatinib and its active metabolite CGP74588 in rat C6 glioma cells.
2008
2008
Population pharmacokinetics of imatinib in children and adults
2526 Background: The aim of this study was to explore the impact of several demographic, biological and pharmacogenetic… 
Highly Cited
2002
Highly Cited
2002
Quantification of the anti-leukemia drug STI571 (Gleevec) and its metabolite (CGP 74588) in monkey plasma using a semi-automated solid phase extraction procedure and liquid chromatography-tandem mass…
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