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CGP 74514A

Known as: CGP-74514A, CGP74514A 
National Institutes of Health

Papers overview

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2017
2017
Abstract 4193: A triple exon-skipping luciferase reporter assay identifies a new CLK inhibitor scaffold
The splicing of pre-mRNA is a critical process in normal cells and is deregulated in cancer. Compounds that modulate this process… 
2012
2012
Role of a DNA Damage Checkpoint Pathway in Ionizing Radiation-Induced Glioblastoma Cell Migration and Invasion
Ionizing radiation (IR) induces a DNA damage response that includes activation of cell cycle checkpoints, leading to cell cycle… 
2011
2011
The Cyclin-dependent kinase 1 Inhibitor CGP74514A inhibits cell proliferation, induces apoptosis and causes downregulation of Cyclin B1and accumulation of p53 in HepG2 cells
Cancer cells are characterized by dysregulation of proliferation, cell cycle and apoptosis. Cell cycle and apoptosis are linked… 
2007
2007
Cyclin-dependent kinase inhibitors block erythrocyte invasion and intraerythrocytic development of Babesia bovis in vitro
SUMMARY Cyclin-dependent kinases (CDKs) are essential for the regulation of the eukaryotic cell cycle. A number of chemicals… 
2007
2007
Regulation of translation factors eIF4GI and 4E-BP1 during recovery of protein synthesis from inhibition by p53
Activation of the tumour suppressor protein p53 rapidly inhibits protein synthesis. This is associated with dephosphorylation and… 
Highly Cited
2005
Highly Cited
2005
Accumulation of p53 and reductions in XIAP abundance promote the apoptosis of prostate cancer cells.
Toward the goal of developing effective treatments for prostate cancers, we examined the effects of cyclin-dependent kinase… 
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