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CES2 protein, human

Known as: Intestinal Carboxylesterase, CE-2, hCE-2 protein, human 
Cocaine esterase (559 aa, ~62 kDa) is encoded by the human CES2 gene. This protein is involved in drug catabolism.
National Institutes of Health

Papers overview

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Highly Cited
2006
Highly Cited
2006
Hydrolase activity from human liver and small intestine microsomes was compared with that of recombinant human carboxylesterases… 
Review
2006
Review
2006
  • T. Imai
  • Drug metabolism and pharmacokinetics
  • 2006
  • Corpus ID: 32949702
Human carboxylesterase 1 (hCE-1, CES1A1, HU1) and carboxylesterase 2 (hCE-2, hiCE, HU3) are a serine esterase involved in both… 
Highly Cited
2005
Highly Cited
2005
The absorption characteristics of temocapril were investigated using Caco-2 cells, and the esterases expressed in Caco-2 cells… 
Highly Cited
2004
Highly Cited
2004
The dose-limiting toxicity of the highly effective anticancer agent 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy… 
Highly Cited
2002
Highly Cited
2002
The bacterial cocaine esterase, cocE, hydrolyzes cocaine faster than any other reported cocaine esterase. Hydrolysis of the… 
Highly Cited
2000
Highly Cited
2000
7-Ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxy-camptothecin (irinotecan; CPT-11) is a prodrug activated by… 
Highly Cited
1997
Highly Cited
1997
A human liver carboxylesterase (hCE-2) that catalyzes the hydrolysis of the benzoyl group of cocaine and the acetyl groups of 4… 
Highly Cited
1997
Highly Cited
1997
A full-length cDNA coding for a putative intestinal carboxylesterase (iCE) was isolated from a human small intestine cDNA library… 
Highly Cited
1996
Highly Cited
1996
Concomitant i.v. use of cocaine and heroin ("speedballing") is prevalent among drug-abusing populations. Heroin is rapidly… 
Highly Cited
1989
Highly Cited
1989
The hatching enzyme is an embryo-secreted enzyme(s) which digests the egg envelope, allowing the embryo to emerge at the time of…