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CES2 protein, human

Known as: Intestinal Carboxylesterase, CE-2, hCE-2 protein, human 
Cocaine esterase (559 aa, ~62 kDa) is encoded by the human CES2 gene. This protein is involved in drug catabolism.
National Institutes of Health

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2015
2015
Twelve new and 10 known protostane triterpenoids were isolated from the rhizome of Alisma orientale. Their structures were… Expand
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2013
2013
Mdr1a-, Bcrp-, and Mrp2-knockout rats are a more practical species for absorption, distribution, metabolism, and excretion (ADME… Expand
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Review
2006
Review
2006
  • Teruko Imai
  • Drug metabolism and pharmacokinetics
  • 2006
  • Corpus ID: 32949702
Human carboxylesterase 1 (hCE-1, CES1A1, HU1) and carboxylesterase 2 (hCE-2, hiCE, HU3) are a serine esterase involved in both… Expand
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Highly Cited
2006
Highly Cited
2006
Hydrolase activity from human liver and small intestine microsomes was compared with that of recombinant human carboxylesterases… Expand
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2002
2002
The bacterial cocaine esterase, cocE, hydrolyzes cocaine faster than any other reported cocaine esterase. Hydrolysis of the… Expand
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2002
2002
Carboxylesterases play a critical role in the bioactivation of the anticancer prodrug irinotecan [7-ethyl-10-[4-(1-piperidino)-1… Expand
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Highly Cited
2000
Highly Cited
2000
7-Ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxy-camptothecin (irinotecan; CPT-11) is a prodrug activated by… Expand
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Highly Cited
1997
Highly Cited
1997
A human liver carboxylesterase (hCE-2) that catalyzes the hydrolysis of the benzoyl group of cocaine and the acetyl groups of 4… Expand
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Highly Cited
1996
Highly Cited
1996
Concomitant i.v. use of cocaine and heroin ("speedballing") is prevalent among drug-abusing populations. Heroin is rapidly… Expand
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1989
1989
The hatching enzyme is an embryo-secreted enzyme(s) which digests the egg envelope, allowing the embryo to emerge at the time of… Expand
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