CES2 protein, human

Known as: Intestinal Carboxylesterase, CE-2, hCE-2 protein, human 
Cocaine esterase (559 aa, ~62 kDa) is encoded by the human CES2 gene. This protein is involved in drug catabolism.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1993-2017
02419932017

Papers overview

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2006
2006
Pyrethroid chemicals are attractive alternatives to the organophosphates (OPs) because of their selective toxicity against pests… (More)
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2006
2006
Pyrethroids are neurotoxic pesticides whose pharmacokinetic behavior plays a role in their potency. This study examined the… (More)
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2005
2005
Twelve single nucleotide polymorphisms (SNPs) in the human CES2 gene, which encodes a carboxylesterase, hCE-2 [human… (More)
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2002
2002
Carboxylesterases play a critical role in the bioactivation of the anticancer prodrug irinotecan [7-ethyl-10-[4-(1-piperidino)-1… (More)
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2001
2001
CPT-11 is a clinically approved anticancer drug used for the treatment of advanced colorectal cancer. Upon administration, the… (More)
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Highly Cited
2000
Highly Cited
2000
7-Ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxy-camptothecin (irinotecan; CPT-11) is a prodrug activated by… (More)
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1999
1999
Human liver carboxylesterases catalyze the hydrolysis of apolar drug or xenobiotic esters into more soluble acid and alcohol… (More)
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1997
Highly Cited
1997
A human liver carboxylesterase (hCE-2) that catalyzes the hydrolysis of the benzoyl group of cocaine and the acetyl groups of 4… (More)
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1997
1997
Carboxylesterases (EC 3.1.1.1) from human liver were purified using Q-Sepharose, Sephadex G-150, isoelectrofocusing and Con A… (More)
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1996
1996
Concomitant i.v. use of cocaine and heroin ("speedballing") is prevalent among drug-abusing populations. Heroin is rapidly… (More)
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