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Inhibition of ceramide synthesis prevents diabetes, steatosis, and cardiovascular disease in rodents. Six different ceramide… Expand Background: Ceramide synthase 2 null mice, which cannot synthesize very-long chain ceramides, display severe hepatopathy. Results… Expand Sphingolipids are important structural components of cell membranes and act as critical regulators of cell function by modulating… Expand A main obstacle to overcome during the treatment of tumors is drug resistance to chemotherapy; emerging studies indicate that a… Expand Chronic kidney disease (CKD) is common, affecting about 10% of the general population, and causing significant morbidity and… Expand The role of ceramide neo-genesis in cellular stress response signaling is gaining increasing attention with recent progress in… Expand (Dihydro)ceramide synthase 2 (cers2, formerly called lass2) is the most abundantly expressed member of the ceramide synthase gene… Expand Ceramide is an important lipid signaling molecule and a key intermediate in sphingolipid biosynthesis. Recent studies have… Expand Synthesis of dihydroceramide is catalyzed by a family of (dihydro)ceramide synthases (CerS), first identified in yeast as… Expand The Lass (longevity-assurance homologue) family members, which are highly conserved among eukaryotes, function in ceramide… Expand