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CEP-9722

Known as: PARP Inhibitor CEP-9722 
A small-molecule prodrug of CEP-8983, a novel 4-methoxy-carbazole inhibitor of the nuclear enzymes poly(ADP-ribose) polymerase (PARP) 1 and 2, with… Expand
National Institutes of Health

Papers overview

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Review
2018
Review
2018
Opinion statementUse of poly(ADP-ribose) polymerase (PARP) inhibitors has greatly increased over the past 5 years. With several… Expand
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2016
2016
Poly (ADP-ribose) polymerase-1 (PARP-1) inhibitors may potentiate chemotherapy by hindering DNA damage repair pathways. CEP-9722… Expand
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2014
2014
PurposePoly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme important in DNA repair. PARP-1 activation at points of DNA… Expand
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2014
2014
As loss of DNA-repair proteins is common in urothelial carcinoma (UC), a rationale can be made to evaluate the activity of poly… Expand
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2013
2013
Humans are constantly exposed to diverse chemical and physical agents that have the potential to damage DNA, such as reactive… Expand
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Review
2010
Review
2010
  • Thomas D. Penning
  • Current opinion in drug discovery & development
  • 2010
  • Corpus ID: 23246166
PARP-1 inhibitors have emerged as a promising therapeutic class of compounds, and numerous PARP inhibitors, including iniparib… Expand
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Highly Cited
2007
Highly Cited
2007
The effect of the potent and selective poly(ADP-ribose) (PAR) polymerase-1 [and PAR polymerase-2] inhibitor CEP-8983 on the… Expand
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