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CE-108

 
National Institutes of Health

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2 relations

Broader (2)

MacrolidesMonosaccharides

Papers overview

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2015
2015
New Rimocidin/CE-108 Derivatives Obtained by a Crotonyl-CoA Carboxylase/Reductase Gene Disruption in Streptomyces diastaticus var. 108: Substrates for the Polyene Carboxamide Synthase PcsA
The rimJ gene, which codes for a crotonyl-CoA carboxylase/reductase, lies within the biosynthetic gene cluster for two… Expand
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2011
2011
Initiation of polyene macrolide biosynthesis: interplay between polyketide synthase domains and modules as revealed via domain swapping, mutagenesis, and heterologous complementation.
Polyene macrolides are important antibiotics used to treat fungal infections in humans. In this work, acyltransferase (AT) domain… Expand
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2009
2009
The pcsA gene from Streptomyces diastaticus var. 108 encodes a polyene carboxamide synthase with broad substrate specificity for polyene amides biosynthesis
Two structurally related polyene macrolides are produced by Streptomyces diastaticus var. 108: rimocidin (3a) and CE-108 (2a… Expand
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2005
2005
A tailoring activity is responsible for generating polyene amide derivatives in Streptomyces diastaticus var. 108.
We recently characterized rimocidin B (3b) and CE-108B (4b) as two polyene amides with improved pharmacological properties… Expand
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2005
2005
Two polyene amides produced by genetically modified Streptomyces diastaticus var. 108.
Streptomyces diastaticus var. 108, a newly isolated strain, was recently characterized as a producer of two polyene macrolide… Expand
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2004
2004
Starter unit choice determines the production of two tetraene macrolides, rimocidin and CE-108, in Streptomyces diastaticus var. 108.
Streptomyces diastaticus var. 108, a newly isolated strain, produces two closely related tetraene macrolides (rimocidin and CE… Expand
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2004
2004
CE-108, a new macrolide tetraene antibiotic.
In the search for strains producing antifungal compounds, a new tetraene macrolide CE-108 (3) has been isolated from culture… Expand
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