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CDP 840

Known as: CDP-840, CDP840 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Pyridines

Papers overview

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Highly Cited
2014
Highly Cited
2014
Arylboration of alkenes by cooperative palladium/copper catalysis.
Arylboration of vinylarenes and methyl crotonate with aryl halides and bis(pinacolato)diboron by cooperative Pd/Cu catalysis has… 
Highly Cited
2011
Highly Cited
2011
Effects of Repeated Treatment with Phosphodiesterase-4 Inhibitors on cAMP Signaling, Hippocampal Cell Proliferation, and Behavior in the Forced-Swim Test
The effects of repeated treatment with the phosphodiesterase-4 (PDE4) inhibitors rolipram, piclamilast, and 4-(2-(3… 
Highly Cited
2006
Highly Cited
2006
Antidepressant-like effects of PDE4 inhibitors mediated by the high-affinity rolipram binding state (HARBS) of the phosphodiesterase-4 enzyme (PDE4) in rats
RationalePhosphodiesterase-4 (PDE4) has two conformation states based on rolipram binding, the high-affinity rolipram binding… 
2005
2005
Rapid synthesis of CDP840 with 2-pyrimidyl vinyl sulfide as a platform.
A rapid synthesis of CDP840 (a potential therapeutic agent for asthma), using 2-pyrimidyl vinyl sulfide as a platform, has been… 
Highly Cited
2003
Highly Cited
2003
Sulfur-ylide-mediated synthesis of functionalized and trisubstituted epoxides with high enantioselectivity; application to the synthesis of CDP-840.
The carbonyl group occupies a position of central importance in organic synthesis as it allows ready functionalization, for… 
2002
2002
Discovery of L-791,943: a potent, selective, non emetic and orally active phosphodiesterase-4 inhibitor.
2002
2002
CDP840. A prototype of a novel class of orally active anti-inflammatory phosphodiesterase 4 inhibitors.
Highly Cited
1997
Highly Cited
1997
The effect of a novel orally active selective PDE4 isoenzyme inhibitor (CDP840) on allergen-induced responses in asthmatic subjects.
Recent studies have suggested that theophylline, a nonspecific phospho-diesterase inhibitor, has useful anti-inflammatory actions… 
Highly Cited
1996
Highly Cited
1996
The inhibition of antigen‐induced eosinophilia and bronchoconstriction by CDP840, a novel stereo‐selective inhibitor of phosphodiesterase type 4
1 The novel tri‐aryl ethane CDP840, is a potent and selective inhibitor of cyclic AMP phosphodiesterase type 4 (PDE 4) extracted… 
1996
1996
Inhibition of bronchospasm and ozone‐induced airway hyperresponsiveness in the guinea‐pig by CDP840, a novel phosphodiesterase type 4 inhibitor
1 The activity of CDP840, a novel, potent and selective cyclic nucleotide phosphodiesterase type 4 (PDE 4) inhibitor, was… 
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