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CDK3 protein, human

Known as: Cyclin-Dependent Kinase 3, Cyclin-Dependent Protein Kinase 3, cyclin-dependent kinase 3 protein, human 
Cyclin-dependent kinase 3 (305 aa, ~35 kDa) is encoded by the human CDK3 gene. This protein may play a role in cell cycle regulation.
National Institutes of Health

Related topics

Related topics

22 relations
CDC7 protein, humanCDK3 geneCDK9 protein, humanCell Cycle Control

Broader (2)

Cyclin-Dependent Kinase 3Protein-Serine-Threonine Kinases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
HuR facilitates cancer stemness of lung cancer cells via regulating miR-873/CDK3 and miR-125a-3p/CDK3 axis
ObjectivesTo study the roles and mechanisms of HuR in cancer stem cell maintenance of lung cancer.ResultsHuR expression was… 
Highly Cited
2017
Highly Cited
2017
miR‐125a‐3p inhibits ERα transactivation and overrides tamoxifen resistance by targeting CDK3 in estrogen receptor–positive breast cancer
Tamoxifen (TAM) is a major adjuvant therapy for patients who are diagnosed with estrogen receptor‐α(ER)–positive breast cancer… 
2017
2017
HuR promotes breast cancer cell proliferation and survival via binding to CDK3 mRNA.
Highly Cited
2016
Highly Cited
2016
Competing endogenous RNA networks of CYP4Z1 and pseudogene CYP4Z2P confer tamoxifen resistance in breast cancer
2016
2016
Phosphorylation of NFAT3 by CDK3 induces cell transformation and promotes tumor growth in skin cancer
The nuclear factor of activated T cells (NFAT) family proteins are transcription factors that regulate the expression of pro… 
Highly Cited
2014
Highly Cited
2014
Cyclin C is a haploinsufficient tumour suppressor
Cyclin C was cloned as a growth-promoting G1 cyclin, and was also shown to regulate gene transcription. Here we report that in… 
Highly Cited
2014
Highly Cited
2014
MiR-873 regulates ERα transcriptional activity and tamoxifen resistance via targeting CDK3 in breast cancer cells
miRNAs (microRNAs) are frequently and aberrantly expressed in many cancers. MiR-873 has been revealed to be downregulated in… 
2013
2013
CDK3 expression and its clinical significance in human nasopharyngeal carcinoma.
The aim of the current study was to investigate the expression of cyclin-dependent kinase 3 (CDK3) in human nasopharyngeal… 
Highly Cited
2008
Highly Cited
2008
Identification of CDK2 substrates in human cell lysates
BackgroundProtein phosphorylation regulates a multitude of biological processes. However, the large number of protein kinases and… 
2002
2002
Effects of Interferon Alpha on the Expression of p21cip1/waf1 and Cell Cycle Distribution in Carcinoid Tumors
Interferon alpha (IFN-α) has been shown to produce antitumor effects in 50–80% of carcinoid tumor patients and has demonstrated… 
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