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CDC20 gene

Known as: CELL DIVISION CYCLE 20, S. CEREVISIAE, HOMOLOG OF, p55CDC, Cell Division Cycle 20 Homolog (S. cerevisiae) Gene 
This gene plays a role in cell cycle progression.
National Institutes of Health

Related topics

Related topics

2 relations
Cell Cycle ControlCell Division Cycle Protein 20 Homolog

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
MAD2 and CDC20 are Upregulated in High-grade Squamous Intraepithelial Lesions and Squamous Cell Carcinomas of the Uterine Cervix
Abnormal expression of the spindle assembly checkpoint proteins causes tumor cell aneuploidy, which has been reported in various… 
2014
2014
Inhibiting tumor growth by targeting liposomally encapsulated CDC20siRNA to tumor vasculature: therapeutic RNA interference.
Review
2010
Review
2010
Cyclin A and Nek2A: APC/C-Cdc20 substrates invisible to the mitotic spindle checkpoint.
Active cyclin B1-Cdk1 (cyclin-dependent kinase 1) keeps cells in mitosis, allowing time for spindle microtubules to capture the… 
Highly Cited
2009
Highly Cited
2009
DNA damage induced p53 downregulates Cdc20 by direct binding to its promoter causing chromatin remodeling
CDC20 is a critical molecule in the Spindle Assembly Checkpoint (SAC). It activates the Anaphase promoting complex and helps a… 
Highly Cited
2007
Highly Cited
2007
Activation of a novel ataxia-telangiectasia mutated and Rad3 related/checkpoint kinase 1–dependent prometaphase checkpoint in cancer cells by diallyl trisulfide, a promising cancer chemopreventive…
Diallyl trisulfide (DATS), a cancer chemopreventive constituent of garlic, inhibits growth of cancer cells by interfering with… 
Highly Cited
2006
Highly Cited
2006
Roles of the anaphase-promoting complex/cyclosome and of its activator Cdc20 in functional substrate binding
The anaphase-promoting complex/cyclosome (APC/C) is a multisubunit ubiquitin-protein ligase that targets for degradation cell… 
Highly Cited
2003
Highly Cited
2003
Xkid Is Degraded in a D-Box, KEN-Box, and A-Box-Independent Pathway
ABSTRACT During mitosis, the Xenopus chromokinesin Kid (Xkid) provides the polar ejection forces needed at metaphase for… 
Highly Cited
2001
Highly Cited
2001
Identification of an Overlapping Binding Domain on Cdc20 for Mad2 and Anaphase-Promoting Complex: Model for Spindle Checkpoint Regulation
ABSTRACT Activation of the anaphase-promoting complex (APC) is required for anaphase initiation and for exit from mitosis in… 
Highly Cited
1998
Highly Cited
1998
Cell cycle arrest in cdc20 mutants of Saccharomyces cerevisiae is independent of Ndc10p and kinetochore function but requires a subset of spindle checkpoint genes.
The spindle checkpoint ensures accurate chromosome segregation by inhibiting anaphase onset in response to altered microtubule… 
Highly Cited
1998
Highly Cited
1998
Dominant alleles of Saccharomyces cerevisiae CDC20 reveal its role in promoting anaphase.
We identified an allele of Saccharomyces cerevisiae CDC20 that exhibits a spindle-assembly checkpoint defect. Previous studies… 
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