CD4-Pseudomonas toxin

Known as: CD4(178)-PE40, recombinant human CD4-Pseudomonas exotoxin, sCD4(178)-PE40

National Institutes of Health

Papers overview

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2006

Anti-HIV-1 immunotoxin 3B3(Fv)-PE38: enhanced potency against clinical isolates in human PBMCs and macrophages, and negligible hepatotoxicity in macaques.

Paul E. Kennedy, Tapan Kumar Bera, +5 authors Ira Pastan
Journal of leukocyte biology
2006

Highly active antiretroviral therapy (HAART) against human immunodeficiency virus type 1 (HIV-1) infection dramatically… (More)

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1995

Interdomain Interactions in the Chimeric Protein Toxin sCD4(178)-PE40: A Differential Scanning Calorimetry (DSC) Study

Stephen R. Davio, Kathryn M. Kienle, Brian Edward Collins
Pharmaceutical Research
1995

The thermal denaturation of the chimeric protein toxin known as sCD4(178)-PE40 (sCD4-PE40) was studied using differential… (More)

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1993

Micro-Characterization of sCD4(178)-PE40 Heterogeneity

Molly McKeough
1993

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1992

Activity of CD4-Pseudomonas exotoxin against cells expressing diverse forms of the HIV and SIV envelope glycoproteins.

Per Ashorn, Bernard Moss, Edward Alexander Berger
Journal of acquired immune deficiency syndromes
1992

CD4(178)-PE40 is a genetically engineered hybrid toxin containing a portion of human CD4 linked to the translocation and ADP… (More)

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1991

Anti-HIV activity of CD4-Pseudomonas exotoxin on infected primary human lymphocytes and monocyte/macrophages.

Per Ashorn, George Englund, María Ángeles Martín, Bernard Moss, Edward Alexander Berger
The Journal of infectious diseases
1991

CD4(178)-PE40 is a recombinant protein consisting of a portion of human CD4 linked to active domains of Pseudomonas aeruginosa… (More)

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1990

Elimination of infectious human immunodeficiency virus from human T-cell cultures by synergistic action of CD4-Pseudomonas exotoxin and reverse transcriptase inhibitors.

Per Ashorn, Bernard Moss, +4 authors Edward Alexander Berger
Proceedings of the National Academy of Sciences…
1990

We have previously described a recombinant protein, designated CD4(178)-PE40, consisting of the human immunodeficiency virus (HIV… (More)

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1990

Recombinant CD4-Pseudomonas exotoxin hybrid protein displays HIV-specific cytotoxicity without affecting MHC class II-dependent functions.

Edward Alexander Berger, Vijay K Chaudhary, +6 authors Bernard Moss
AIDS research and human retroviruses
1990

The present study describes several in vitro activities of CD4(178)-PE40, a recombinant protein containing a portion of human CD4… (More)

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1990

Anti-HIV effects of CD4-Pseudomonas exotoxin on human lymphocyte and monocyte/macrophage cell lines.

Per Ashorn, Bernard Moss, Edward Alexander Berger
Annals of the New York Academy of Sciences
1990

CD4(178)-PE40 is a recombinant protein consisting of the HIV envelope glycoprotein-binding region of human CD4 linked to active… (More)

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1989

CD4-Pseudomonas exotoxin hybrid protein blocks the spread of human immunodeficiency virus infection in vitro and is active against cells expressing the envelope glycoproteins from diverse primate…

Edward Alexander Berger, Kathleen A. Clouse, +4 authors Bernard Moss
Proceedings of the National Academy of Sciences…
1989

We previously described an unusual recombinant protein, designated CD4(178)-PE40, containing the gp120 binding region of human… (More)

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CD4-Pseudomonas toxin

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