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CD4-Pseudomonas toxin

Known as: CD4(178)-PE40, recombinant human CD4-Pseudomonas exotoxin, sCD4(178)-PE40 
National Institutes of Health

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Related topics

2 relations

Broader (2)

ExotoxinsRecombinant Proteins

Papers overview

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2006
2006
Anti‐HIV‐1 immunotoxin 3B3(Fv)‐PE38: enhanced potency against clinical isolates in human PBMCs and macrophages, and negligible hepatotoxicity in macaques
Highly active antiretroviral therapy (HAART) against human immunodeficiency virus type 1 (HIV‐1) infection dramatically… 
2004
2004
Interdomain Interactions in the Chimeric Protein Toxin sCD4(178)-PE40: A Differential Scanning Calorimetry (DSC) Study
The thermal denaturation of the chimeric protein toxin known as sCD4(178)-PE40 (sCD4-PE40) was studied using differential… 
1993
1993
Micro-Characterization of sCD4(178)-PE40 Heterogeneity
1992
1992
Activity of CD4-Pseudomonas exotoxin against cells expressing diverse forms of the HIV and SIV envelope glycoproteins.
CD4(178)-PE40 is a genetically engineered hybrid toxin containing a portion of human CD4 linked to the translocation and ADP… 
1991
1991
Anti-HIV activity of CD4-Pseudomonas exotoxin on infected primary human lymphocytes and monocyte/macrophages.
CD4(178)-PE40 is a recombinant protein consisting of a portion of human CD4 linked to active domains of Pseudomonas aeruginosa… 
Highly Cited
1990
Highly Cited
1990
Elimination of infectious human immunodeficiency virus from human T-cell cultures by synergistic action of CD4-Pseudomonas exotoxin and reverse transcriptase inhibitors.
We have previously described a recombinant protein, designated CD4(178)-PE40, consisting of the human immunodeficiency virus (HIV… 
1990
1990
Recombinant CD4-Pseudomonas exotoxin hybrid protein displays HIV-specific cytotoxicity without affecting MHC class II-dependent functions.
The present study describes several in vitro activities of CD4(178)-PE40, a recombinant protein containing a portion of human CD4… 
1990
1990
Anti‐HIV Effects of CD4‐Pseudomonas Exotoxin on Human Lymphocyte and Monocyte/Macrophage Cell Lines
CD4(178)-PE40 is a recombinant protein consisting of the HIV envelope glycoprotein-binding region of human CD4 linked to active… 
Highly Cited
1989
Highly Cited
1989
CD4-Pseudomonas exotoxin hybrid protein blocks the spread of human immunodeficiency virus infection in vitro and is active against cells expressing the envelope glycoproteins from diverse primate…
We previously described an unusual recombinant protein, designated CD4(178)-PE40, containing the gp120 binding region of human… 
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