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CCT 137690
Known as:
CCT-137690
, CCT137690
National Institutes of Health
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2019
2019
Effect of CCT137690 on long non-coding RNA expression profiles in MCF-7 and MDA-MB-231 cell lines
Tuğçe Balcı Okcanoğlu
,
Ç. Kayabaşı
,
Cumhur Gündüz
Bosnian journal of basic medical sciences
2019
Corpus ID: 197664064
Long non-coding RNAs (lncRNAs) are involved in a range of biological processes, such as cellular differentiation, migration…
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2019
2019
Identification and evaluation of novel drug combinations of Aurora kinase inhibitor CCT137690 for enhanced efficacy in oral cancer cells
M. Furqan
,
Z. Huma
,
+7 authors
A. Faisal
Cell cycle
2019
Corpus ID: 197665567
ABSTRACT Oral cancer is the most prevalent subtype of head and neck cancers and arises mainly from squamous cells of the oral…
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2019
2019
Abstract 298: Identification and evaluation of novel drug combinations with aurora kinase inhibitor CCT137690 for enhanced efficacy in 2D monolayer and 3D spheroid model of oral cancer cells
M. Furqan
,
Zainab Ashfaq
,
+5 authors
A. Faisal
Experimental and Molecular Therapeutics
2019
Corpus ID: 219269694
Background: Oral cancer is the most prevalent subtype of head and neck cancers with a high incidence among men in South-Central…
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Highly Cited
2017
Highly Cited
2017
Inhibition of Aurora Kinase A Induces Necroptosis in Pancreatic Carcinoma.
Yangchun Xie
,
Shan Zhu
,
+8 authors
D. Tang
Gastroenterology
2017
Corpus ID: 206247539
BACKGROUND & AIMS Induction of nonapoptotic cell death could be an approach to eliminate apoptosis-resistant tumors. We…
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2014
2014
Inhibition of Aurora B by CCT137690 sensitizes colorectal cells to radiotherapy
Xiao-yu Wu
,
Wentao Liu
,
+6 authors
Xue-Quan Yao
Journal of experimental & clinical cancer…
2014
Corpus ID: 3547305
Colorectal cancer is the third most commonly diagnosed cancer worldwide. Although surgery remains the best treatment for this…
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Review
2013
Review
2013
Gene mutations and molecularly targeted therapies in acute myeloid leukemia.
E. Hatzimichael
,
G. Georgiou
,
L. Benetatos
,
E. Briasoulis
American journal of blood research
2013
Corpus ID: 1827235
Acute myelogenous leukemia (AML) can progress quickly and without treatment can become fatal in a short period of time. However…
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Highly Cited
2012
Highly Cited
2012
Selective FLT3 inhibition of FLT3-ITD+ acute myeloid leukaemia resulting in secondary D835Y mutation: a model for emerging clinical resistance patterns
A. Moore
,
A. Faisal
,
+15 authors
S. Linardopoulos
Leukemia
2012
Corpus ID: 4874469
Acquired resistance to selective FLT3 inhibitors is an emerging clinical problem in the treatment of FLT3-ITD+ acute myeloid…
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Highly Cited
2011
Highly Cited
2011
The Aurora Kinase Inhibitor CCT137690 Downregulates MYCN and Sensitizes MYCN-Amplified Neuroblastoma In Vivo
A. Faisal
,
L. Vaughan
,
+11 authors
S. Linardopoulos
Molecular Cancer Therapeutics
2011
Corpus ID: 22148120
Aurora kinases regulate key stages of mitosis including centrosome maturation, spindle assembly, chromosome segregation, and…
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Highly Cited
2010
Highly Cited
2010
Imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases: lead optimization studies toward the identification of an orally bioavailable preclinical development candidate.
V. Bavetsias
,
J. Large
,
+19 authors
E. McDonald
Journal of medicinal chemistry
2010
Corpus ID: 8421191
Lead optimization studies using 7 as the starting point led to a new class of imidazo[4,5-b]pyridine-based inhibitors of Aurora…
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2010
2010
Dual Inhibition of Aurora and FLT3 Kinases by CCT137690: A Novel Treatment Strategy Against FLT3-ITD Positive AML In Vitro and In Vivo
A. Moore
,
A. Faisal
,
+11 authors
S. Linardopoulos
2010
Corpus ID: 73892548
Abstract 3289 The Aurora kinases are a family of serine-threonine kinases that play key roles in different stages of mitosis…
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