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CCT 137690

Known as: CCT-137690, CCT137690 
 
National Institutes of Health

Papers overview

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2019
2019
Effect of CCT137690 on long non-coding RNA expression profiles in MCF-7 and MDA-MB-231 cell lines
Long non-coding RNAs (lncRNAs) are involved in a range of biological processes, such as cellular differentiation, migration… Expand
2019
2019
Abstract 298: Identification and evaluation of novel drug combinations with aurora kinase inhibitor CCT137690 for enhanced efficacy in 2D monolayer and 3D spheroid model of oral cancer cells
Background: Oral cancer is the most prevalent subtype of head and neck cancers with a high incidence among men in South-Central… Expand
2017
2017
Inhibition of Aurora Kinase A Induces Necroptosis in Pancreatic Carcinoma.
BACKGROUND & AIMS Induction of nonapoptotic cell death could be an approach to eliminate apoptosis-resistant tumors. We… Expand
2014
2014
Inhibition of Aurora B by CCT137690 sensitizes colorectal cells to radiotherapy
Colorectal cancer is the third most commonly diagnosed cancer worldwide. Although surgery remains the best treatment for this… Expand
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Review
2013
Review
2013
Gene mutations and molecularly targeted therapies in acute myeloid leukemia.
Acute myelogenous leukemia (AML) can progress quickly and without treatment can become fatal in a short period of time. However… Expand
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2013
2013
Abstract 3816: DNA variation at BARD1 predicts response to aurora kinase inhibition in neuroblastoma.
Background: Neuroblastoma remains responsible for a disproportionately high number of pediatric cancer deaths, necessitating… Expand
Highly Cited
2012
Highly Cited
2012
Selective FLT3 inhibition of FLT3-ITD+ acute myeloid leukaemia resulting in secondary D835Y mutation: a model for emerging clinical resistance patterns
Acquired resistance to selective FLT3 inhibitors is an emerging clinical problem in the treatment of FLT3-ITD+ acute myeloid… Expand
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Highly Cited
2011
Highly Cited
2011
The Aurora Kinase Inhibitor CCT137690 Downregulates MYCN and Sensitizes MYCN-Amplified Neuroblastoma In Vivo
Aurora kinases regulate key stages of mitosis including centrosome maturation, spindle assembly, chromosome segregation, and… Expand
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Highly Cited
2010
Highly Cited
2010
Imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases: lead optimization studies toward the identification of an orally bioavailable preclinical development candidate.
Lead optimization studies using 7 as the starting point led to a new class of imidazo[4,5-b]pyridine-based inhibitors of Aurora… Expand
2010
2010
Dual Inhibition of Aurora and FLT3 Kinases by CCT137690: A Novel Treatment Strategy Against FLT3-ITD Positive AML In Vitro and In Vivo
Abstract 3289 The Aurora kinases are a family of serine-threonine kinases that play key roles in different stages of mitosis… Expand
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