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CCNC gene

Known as: CCNC, CYCLIN C, CycC 
This gene plays a role in the modulation of gene transcription.
National Institutes of Health

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CCNC wt Allele
Cyclin CHomo sapiensTranscription InitiationTranscriptional Activation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19
Somatic mutations in exon 2 of the RNA polymerase II transcriptional Mediator subunit MED12 occur at high frequency in uterine… 
2017
2017
A molecular dynamics investigation of CDK8/CycC and ligand binding: conformational flexibility and implication in drug discovery
Abnormal activity of cyclin-dependent kinase 8 (CDK8) along with its partner protein cyclin C (CycC) is a common feature of many… 
Highly Cited
2011
Highly Cited
2011
The structure of CDK8/CycC implicates specificity in the CDK/cyclin family and reveals interaction with a deep pocket binder.
Review
2011
Review
2011
Dysregulation of CDK8 and Cyclin C in tumorigenesis.
Highly Cited
2008
Highly Cited
2008
Comparative genomics supports a deep evolutionary origin for the large, four-module transcriptional mediator complex
The multisubunit Mediator (MED) complex bridges DNA-bound transcriptional regulators to the RNA polymerase II (PolII) initiation… 
Highly Cited
2007
Highly Cited
2007
Distinct roles for Mediator Cdk8 module subunits in Drosophila development
Mediator (MED) is a conserved multisubunit complex bridging transcriptional activators and repressors to the general RNA… 
Highly Cited
2006
Highly Cited
2006
The cyclin-dependent kinase 8 module sterically blocks Mediator interactions with RNA polymerase II
CDK8 (cyclin-dependent kinase 8), along with CycC, Med12, and Med13, form a repressive module (the Cdk8 module) that prevents RNA… 
Highly Cited
2004
Highly Cited
2004
Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover.
2000
2000
Higher levels of cell proliferation rate and cyclin CycD3 expression in the Arabidopsis amp1 mutant.
Cytokinins are involved in plant cell proliferation leading to plant growth and morphogenesis. The amp1 mutant of Arabidopsis has… 
1995
1995
Bradyrhizobium japonicum cytochrome c550 is required for nitrate respiration but not for symbiotic nitrogen fixation
Bradyrhizobium japonicum possesses three soluble c-type cytochromes, c550, c552, and c555. The genes for cytochromes c552 (cycB… 
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