CBL gene

Known as: CASITAS B-LINEAGE LYMPHOMA PROTOONCOGENE, C-CBL, ONCOGENE CBL2 
This gene plays a role in signal transduction and the regulation of protein degradation.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1990-2017
0204019902017

Papers overview

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Highly Cited
2009
Highly Cited
2009
Acquired uniparental disomy (aUPD) is a common feature of cancer genomes, leading to loss of heterozygosity. aUPD is associated… (More)
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Highly Cited
2009
Highly Cited
2009
Juvenile myelomonocytic leukemia is an aggressive myeloproliferative disorder characterized by malignant transformation in the… (More)
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Highly Cited
2008
Highly Cited
2008
Two types of acquired loss of heterozygosity are possible in cancer: deletions and copy-neutral uniparental disomy (UPD… (More)
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Highly Cited
2002
Highly Cited
2002
How Cbl family proteins regulate T cell responses is unclear. We found that c-Cbl Cbl-b double knock-out (dKO) T cells became… (More)
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Highly Cited
2002
Highly Cited
2002
In epithelial cells, tyrosine kinases induce the tyrosine phosphorylation and ubiquitination of the E-cadherin complex, which… (More)
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Highly Cited
2000
Highly Cited
2000
Ubiquitin-protein ligases (E3s) regulate diverse cellular processes by mediating protein ubiquitination. The c-Cbl proto-oncogene… (More)
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Highly Cited
2000
Highly Cited
2000
Overexpression of HER-2/ErbB-2, a homologue of the epidermal growth factor receptor, is associated with poor prognosis, and an… (More)
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Highly Cited
1999
Highly Cited
1999
Ubiquitination of receptor protein-tyrosine kinases (RPTKs) terminates signaling by marking active receptors for degradation. c… (More)
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Highly Cited
1999
Highly Cited
1999
Receptor desensitization is accomplished by accelerated endocytosis and degradation of ligand-receptor complexes. An in vitro… (More)
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Highly Cited
1998
Highly Cited
1998
Ligand-induced down-regulation of two growth factor receptors, EGF receptor (ErbB-1) and ErbB-3, correlates with differential… (More)
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