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CBL gene

Known as: CASITAS B-LINEAGE LYMPHOMA PROTOONCOGENE, C-CBL, ONCOGENE CBL2 
This gene plays a role in signal transduction and the regulation of protein degradation.
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2010
Review
2010
Myeloproliferative neoplasms (MPNs) originate from genetically transformed hematopoietic stem cells that retain the capacity for… Expand
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Highly Cited
2008
Highly Cited
2008
Two types of acquired loss of heterozygosity are possible in cancer: deletions and copy-neutral uniparental disomy (UPD… Expand
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Highly Cited
2003
Highly Cited
2003
Growth factors stimulate specific receptor tyrosine kinases, but subsequent receptor endocytosis terminates signaling. The… Expand
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Highly Cited
2001
Highly Cited
2001
The c-Cbl protooncogene is a negative regulator for several receptor tyrosine kinases (RTKs) through its ability to promote their… Expand
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Highly Cited
2000
Highly Cited
2000
Ubiquitin-protein ligases (E3s) regulate diverse cellular processes by mediating protein ubiquitination. The c-Cbl proto-oncogene… Expand
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Highly Cited
1999
Highly Cited
1999
Ubiquitination of receptor protein-tyrosine kinases (RPTKs) terminates signaling by marking active receptors for degradation. c… Expand
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Highly Cited
1999
Highly Cited
1999
ABSTRACT The four members of the ErbB family of receptor tyrosine kinases are involved in a complex array of combinatorial… Expand
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Highly Cited
1999
Highly Cited
1999
c-Cbl plays a negative regulatory role in tyrosine kinase signaling by an as yet undefined mechanism. We demonstrate here, using… Expand
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Highly Cited
1999
Highly Cited
1999
Ligand-induced activation of surface receptors, including the epidermal growth factor receptor (EGFR), is followed by a… Expand
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Highly Cited
1998
Highly Cited
1998
Cbl is the product of the protooncogene c-cbl and is involved in T cell antigen receptor (TCR)-mediated signaling. To understand… Expand
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