FAQ

CBFB/MYH11 FUSION GENE

Known as: CBFbeta-MYH11 Fusion Gene, CBFbeta-SMMHC Fusion Gene, CBFbeta/SMMHC Fusion Gene 
A fusion gene that results from a chromosomal inversion inv(16)(p13q22) which fuses the 5' portion of the CBFB gene with the 3' part of the MYH11… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1998-2016
01219982016

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Related topics

2 relations
CBFbeta-MYH11 fusion proteinTranscriptional Repression

Related mentions per year

Related mentions per year

1977-2018
197019801990200020102020
CBFB/MYH11 FUSION GENE
Transcriptional Repression
CBFbeta-MYH11 fusion protein

Papers overview

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2017
2017
Rare CBFB-MYH11 cryptic rearrangement in acute myeloid leukemia with ins(16)(p13.1q22q22)
Acute myeloid leukemia (AML) with inv(16)(p13.1q22) or t(16;16)(p13.1;q22) is defined by the World Health Organization (WHO… (More)
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2016
2016
Treatment-related acute myeloid leukemia with type D CBFB-MYH11 after chemotherapy and radiotherapy in non-hodgkin lymphoma: a rare case report
Treatment-related Acute Myeloid Leukemia (t-AML) is among complications which occur after treatment of primary malignancies due… (More)
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2013
2013
[Clinical analysis of acute myeloid leukemia with CBFB-MYH11-positive].
The study was aimed to investigate the clinical characteristics of acute myeloid leukemia (AML) with CBFB-MYH11 gene. The… (More)
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2010
2010
Cbfb/Runx1 repression-independent blockage of differentiation and accumulation of Csf2rb-expressing cells by Cbfb-MYH11.
It is known that CBFB-MYH11, the fusion gene generated by inversion of chromosome 16 in human acute myeloid leukemia, is… (More)
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2009
2009
Runx2 induces acute myeloid leukemia in cooperation with Cbfbeta-SMMHC in mice.
The core-binding factor (CBF) is a master regulator of developmental and differentiation programs, and CBF alterations are… (More)
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2008
2008
Cbfbeta-SMMHC impairs differentiation of common lymphoid progenitors and reveals an essential role for RUNX in early B-cell development.
The core-binding factor (CBF)-associated leukemia fusion protein CBFbeta-SMMHC impairs myeloid and lymphoid differentiation. By… (More)
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2006
2006
Human CD34+ cells expressing the inv(16) fusion protein exhibit a myelomonocytic phenotype with greatly enhanced proliferative ability.
The t(16:16) and inv(16) are associated with FAB M4Eo myeloid leukemias and result in fusion of the CBFB gene to the MYH11 gene… (More)
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2003
2003
Monitoring AML1-ETO and CBFbeta-MYH11 transcripts in acute myeloid leukemia.
The core-binding factor (CBF) leukemias comprise acute myeloid leukemia (AML) with t(8;21) and inv(16)/t(16;16), characterized by… (More)
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2002
2002
Multimerization via its myosin domain facilitates nuclear localization and inhibition of core binding factor (CBF) activities by the CBFbeta-smooth muscle myosin heavy chain myeloid leukemia…
In CBFbeta-SMMHC, core binding factor beta (CBFbeta) is fused to the alpha-helical rod domain of smooth muscle myosin heavy chain… (More)
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1998
1998
CBFbeta-SMMHC, expressed in M4eo acute myeloid leukemia, reduces p53 induction and slows apoptosis in hematopoietic cells exposed to DNA-damaging agents.
CBFbeta-SMMHC is expressed in M4Eo acute myeloid leukemia (AML) as a result of inv(16), but how it contributes to leukemogenesis… (More)
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