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CBFB/MYH11 FUSION GENE
Known as:
CBFbeta-MYH11 Fusion Gene
, CBFbeta-SMMHC Fusion Gene
, CBFbeta/SMMHC Fusion Gene
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A fusion gene that results from a chromosomal inversion inv(16)(p13q22) which fuses the 5' portion of the CBFB gene with the 3' part of the MYH11…
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National Institutes of Health
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Related topics
Related topics
2 relations
CBFbeta-MYH11 fusion protein
Transcriptional Repression
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2018
Highly Cited
2018
Circular RNA circ-CBFB promotes proliferation and inhibits apoptosis in chronic lymphocytic leukemia through regulating miR-607/FZD3/Wnt/β-catenin pathway.
L. Xia
,
Linlin Wu
,
+4 authors
R. Xia
Biochemical and Biophysical Research…
2018
Corpus ID: 49210385
2017
2017
Chd7 deficiency delays leukemogenesis in mice induced by Cbfb-MYH11.
T. Zhen
,
E. Kwon
,
+6 authors
P. Liu
Blood
2017
Corpus ID: 19840835
Inversion of chromosome 16 is a consistent finding in patients with acute myeloid leukemia subtype M4 with eosinophilia, which…
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2010
2010
Cbfb/Runx1 repression-independent blockage of differentiation and accumulation of Csf2rb-expressing cells by Cbfb-MYH11.
R. K. Hyde
,
Y. Kamikubo
,
+4 authors
P. Liu
Blood
2010
Corpus ID: 206882091
It is known that CBFB-MYH11, the fusion gene generated by inversion of chromosome 16 in human acute myeloid leukemia, is…
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2008
2008
Cbfbeta-SMMHC impairs differentiation of common lymphoid progenitors and reveals an essential role for RUNX in early B-cell development.
Ya-Huei Kuo
,
R. Gerstein
,
L. Castilla
Blood
2008
Corpus ID: 25001804
The core-binding factor (CBF)-associated leukemia fusion protein CBFbeta-SMMHC impairs myeloid and lymphoid differentiation. By…
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2007
2007
CBFB-MYH11 hinders early T-cell development and induces massive cell death in the thymus.
Ling Zhao
,
J. Cannons
,
+6 authors
P. Liu
Blood
2007
Corpus ID: 18642886
Recent studies suggest that the chromosome 16 inversion, associated with acute myeloid leukemia M4Eo, takes place in…
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2006
2006
Human CD34+ cells expressing the inv(16) fusion protein exhibit a myelomonocytic phenotype with greatly enhanced proliferative ability.
M. Wunderlich
,
O. Krejčí
,
Junping Wei
,
J. Mulloy
Blood
2006
Corpus ID: 297608
The t(16:16) and inv(16) are associated with FAB M4Eo myeloid leukemias and result in fusion of the CBFB gene to the MYH11 gene…
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Highly Cited
2004
Highly Cited
2004
Identification of genes that synergize with Cbfb-MYH11 in the pathogenesis of acute myeloid leukemia.
L. Castilla
,
P. Perrat
,
+11 authors
P. Liu
Proceedings of the National Academy of Sciences…
2004
Corpus ID: 39272886
Acute myeloid leukemia subtype M4 with eosinophilia is associated with a chromosome 16 inversion that creates a fusion gene CBFB…
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1998
1998
CBFbeta-SMMHC, expressed in M4eo acute myeloid leukemia, reduces p53 induction and slows apoptosis in hematopoietic cells exposed to DNA-damaging agents.
M. Britos-Bray
,
M. Ramírez
,
+4 authors
A. Friedman
Blood
1998
Corpus ID: 25329162
CBFbeta-SMMHC is expressed in M4Eo acute myeloid leukemia (AML) as a result of inv(16), but how it contributes to leukemogenesis…
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1996
1996
A Conserved Cysteine Residue in the runt Homology Domain of AML1 Is Required for the DNA Binding Ability and the Transforming Activity on Fibroblasts*
M. Kurokawa
,
Tomoyuki N. Tanaka
,
+5 authors
H. Hirai
Journal of Biological Chemistry
1996
Corpus ID: 357815
The AML1 gene encodes DNA-binding proteins that contain the runt homology domain and is found at the breakpoints of t(8;21), t(3…
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1996
1996
The gene product of CBFB-MYH11.
D. Claxton
,
Q. Xie
,
S. Patel
,
A. Deisseroth
,
S. Kornblau
Leukemia
1996
Corpus ID: 21453950
The inversion(16)(p13;q22) gives rise to chimeric transcripts CBFB-MYH11. To date however, no reports have described the full…
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