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CASP4 protein, human

Known as: CASP-4, caspase 4, apoptosis-related cysteine protease protein, human, ICH-2 protein, human 
Caspase-4 (377 aa, ~43 kDa) is encoded by the human CASP4 gene. This protein plays a role in both proteolysis and apoptosis.
National Institutes of Health

Related topics

Related topics

30 relations
ApoptosisCASP2 protein, humanCASP4 geneCASP4 wt Allele

Broader (2)

Caspases, InitiatorCysteine Endopeptidases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Mechanisms of Gasdermin Family Members in Inflammasome Signaling and Cell Death.
Highly Cited
2015
Highly Cited
2015
Caspase‐4 mediates non‐canonical activation of the NLRP3 inflammasome in human myeloid cells
Inflammasome activation culminates in activation of caspase‐1, which leads to the maturation and subsequent release of cytokines… 
Highly Cited
2014
Highly Cited
2014
Noncanonical inflammasome activation of caspase-4/caspase-11 mediates epithelial defenses against enteric bacterial pathogens.
Highly Cited
2012
Highly Cited
2012
Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1
Inflammasomes are cytosolic multiprotein complexes assembled by intracellular nucleotide-binding oligomerization domain (NOD… 
Highly Cited
2009
Highly Cited
2009
Flavonoids activated caspases for apoptosis in human glioblastoma T98G and U87MG cells but not in human normal astrocytes
Human glioblastoma is a deadly brain cancer that continues to defy all current therapeutic strategies. The authors induced… 
Review
2007
Review
2007
Inflammatory caspases and inflammasomes: master switches of inflammation
Fifteen years have passed since the cloning and characterization of the interleukin-1β-converting enzyme (ICE/caspase-1), the… 
Highly Cited
2005
Highly Cited
2005
Bortezomib inhibits PKR-like endoplasmic reticulum (ER) kinase and induces apoptosis via ER stress in human pancreatic cancer cells.
Bortezomib (Velcade, formerly known as PS-341) is a boronic acid dipeptide derivative that is a selective and potent inhibitor of… 
Review
2003
Review
2003
Apoptosis and interferons: Role of interferon-stimulated genes as mediators of apoptosis
IFNs are a family of cytokines with pleiotropic biological effects mediated by scores of responsive genes. IFNs were the first… 
Highly Cited
2002
Highly Cited
2002
Interleukin-1F7B (IL-1H4/IL-1F7) is processed by caspase-1 and mature IL-1F7B binds to the IL-18 receptor but does not induce IFN-gamma production.
We have recently reported the identification of four novel members of the interleukin-1 (IL-1) family which we designated as IL-1… 
Highly Cited
1997
Highly Cited
1997
Characterization of seven murine caspase family members
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