CAAX-protein geranylgeranyltransferase activity

Known as: geranylgeranyltransferase type I activity, GGTase-I activity, type I protein geranyl-geranyltransferase activity 
Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1991-2016
01219912016

Papers overview

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2016
2016
Cholesterol 24-hydroxylase (CYP46A1) is responsible for brain cholesterol elimination and therefore plays a crucial role in the… (More)
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2014
2014
Protein prenylation is required for a variety of growth and developmental processes in flowering plants. Here we report the… (More)
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2008
2008
PURPOSE To determine the effects of inhibition of protein geranylgeranyltransferase type I (GGTase-I), which isoprenylates so… (More)
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2007
2007
Protein geranylgeranyltransferase type I (GGTase-I) is responsible for the posttranslational lipidation of CAAX proteins such as… (More)
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2003
2003
A number of small GTPases are involved in cancer cell proliferation, migration and invasion. They need to be prenylated for full… (More)
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1998
1998
Rab GTPases are post-translationally modified by addition of geranylgeranyl moieties to carboxyl-terminal cysteine residues. For… (More)
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1993
1993
The product of the Schizosaccharomyces pombe cwg2+ gene is involved in the biosynthesis of beta-D-glucan. When grown at the non… (More)
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Highly Cited
1991
Highly Cited
1991
Several proteins have been shown to be post-translationally modified on a specific C-terminal cysteine residue by either of two… (More)
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1991
1991
Farnesyl-protein transferase (FTase) purified from rat or bovine brain is an alpha/beta heterodimer, comprised of subunits having… (More)
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