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CA 074 methyl ester

Known as: CA074Me 
National Institutes of Health

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CA-074Me

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Dipeptides

Papers overview

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2017
2017
Trans-crocetin improves amyloid-β degradation in monocytes from Alzheimer's Disease patients
Highly Cited
2015
Highly Cited
2015
Multiple Cathepsins Promote Pro–IL-1β Synthesis and NLRP3-Mediated IL-1β Activation
Sterile particles induce robust inflammatory responses that underlie the pathogenesis of diseases like silicosis, gout, and… 
2014
2014
Role of cathepsin B in regulating migration and invasion of fibroblast‐like synoviocytes into inflamed tissue from patients with rheumatoid arthritis
Cathepsin B (CB), an important proteinase that participates in joint destruction in rheumatoid arthritis (RA), exhibits higher… 
Highly Cited
2014
Highly Cited
2014
Brain pyroglutamate amyloid-β is produced by cathepsin B and is reduced by the cysteine protease inhibitor E64d, representing a potential Alzheimer's disease therapeutic.
Pyroglutamate amyloid-β peptides (pGlu-Aβ) are particularly pernicious forms of amyloid-β peptides (Aβ) present in Alzheimer's… 
Highly Cited
2012
Highly Cited
2012
Impairment of lysosomal integrity by B10, a glycosylated derivative of betulinic acid, leads to lysosomal cell death and converts autophagy into a detrimental process
In this study, we report a novel mechanism of action for a cytotoxic derivative of betulinic acid (BA). B10 is a semi-synthetic… 
Highly Cited
2008
Highly Cited
2008
Inhibitors of Cathepsin B Improve Memory and Reduce β-Amyloid in Transgenic Alzheimer Disease Mice Expressing the Wild-type, but Not the Swedish Mutant, β-Secretase Site of the Amyloid Precursor…
Elucidation of Aβ-lowering agents that inhibit processing of the wild-type (WT) β-secretase amyloid precursor protein (APP) site… 
Highly Cited
2006
Highly Cited
2006
New insights on the use of desipramine as an inhibitor for acid ceramidase
Highly Cited
2005
Highly Cited
2005
Inhibition of cathepsin B reduces β-amyloid production in regulated secretory vesicles of neuronal chromaffin cells: evidence for cathepsin B as a candidate β-secretase of Alzheimer's disease
Abstract The regulated secretory pathway of neurons is the major source of extracellular Aβ that accumulates in Alzheimer's… 
Highly Cited
2005
Highly Cited
2005
Overexpression of Stefin A in Human Esophageal Squamous Cell Carcinoma Cells Inhibits Tumor Cell Growth, Angiogenesis, Invasion, and Metastasis
Purpose: Evidence is accumulating that an inverse correlation exists between stefin A level and malignant progression. The aim of… 
Highly Cited
1994
Highly Cited
1994
Inhibition of bone resrption by selctive inactivators of cysteine proteinases
Incativators of cystein proteinases (CPs) were tested as inhibitors of bone resorption in vitro and in vivo. The following four… 
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