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C-1748

 
National Institutes of Health

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2014
2014
High CYP3A4 expression sensitizes tumor cells to certain antitumor agents while for others it can lower their therapeutic… Expand
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2013
2013
Induction of proteins involved in drug metabolism and in drug delivery has a significant impact on drug-drug interactions and on… Expand
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2012
2012
The narrow "therapeutic window" of anti-tumour therapy may be the result of drug metabolism leading to the activation or… Expand
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2010
2010
C-1748 is a DNA-binding agent with potent antitumor activity, especially towards prostate and colon carcinoma xenografts in mice… Expand
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2007
2007
Nitroacridines are potent DNA-binding and cytotoxic agents in cancer cells, but could not be developed clinically due to high… Expand
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2007
2007
Chemotherapy in prostate cancer (CaP) even as an adjunct has not been a success. In this communication, we report the pre… Expand
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2006
2006
We have developed a group of 4-substituted-1-nitroacridines with potent anti-tumor activity against prostate cancer and less… Expand
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2005
2005
5885 Development of a chemotherapeutic regimen against prostate cancer (CaP) is a challenge. We have identified a novel… Expand
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2005
2005
The anticancer effect of 1-nitro-9-hydroxyethylamino acridine (C-857), a compound belonging to the 1-nitroacridine class, has… Expand
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2004
2004
Proc Amer Assoc Cancer Res, Volume 45, 2004 3034 Aromatase inhibitors (anastrozole, letrozole, and exemestane) are considered… Expand
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