Buthionine Sulfoximine

Known as: Buthionine Sulfoximine [Chemical/Ingredient], Butanoic Acid, 2-Amino-4-(S-butylsulfonimidoyl)-, S-(3-Amino-3-carboxypropyl)-S-butylsulfoximine 
A synthetic amino acid. Buthionine sulfoximine irreversibly inhibits gamma-glutamylcysteine synthase, thereby depleting cells of glutathione, a… (More)

Topic mentions per year

Topic mentions per year

1970-2018
05010019702018

Papers overview

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Highly Cited
2009
Highly Cited
2009
BACKGROUND Hysterectomy and bilateral salpingo-oophorectomy (BSO) is the standard surgery for stage I endometrial cancer… (More)
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2006
2006
Oxidative stress and genomic rearrangements play a role in cancer development. l-Buthionine-sulfoximine (BSO) induces oxidative… (More)
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Highly Cited
2004
Highly Cited
2004
AbstractClinical application of anticancer agents has been often hampered by toxicity against normal cells, so the achievement of… (More)
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Highly Cited
1999
Highly Cited
1999
Arsenic trioxide (As2O3) induces clinical remission in acute promyelocytic leukemia (APL) with minimal toxicity and apoptosis in… (More)
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1998
1998
L-S,R-buthionine sulfoximine (L-S,R BSO) is a potent specific inhibitor of gamma-glutamylcysteine synthetase, the rate-limiting… (More)
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Highly Cited
1997
Highly Cited
1997
BACKGROUND Increased intracellular glutathione has long been associated with tumor cell resistance to various cytotoxic agents… (More)
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1994
1994
PURPOSE A phase I dose-escalation trial of intravenous (IV) L-buthionine-SR-sulfoximine (BSO) with melphalan (L-PAM) was… (More)
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1992
1992
Oxygen free radicals have been implicated in the pathogenesis of brain injury induced by ischemia/reperfusion. We studied the… (More)
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Highly Cited
1985
Highly Cited
1985
The optimum integration of chemotherapy and irradiation is of potential clinical significance in the treatment of ovarian cancer… (More)
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Highly Cited
1979
Highly Cited
1979
Buthionine sulfoximine (S-n-butyl homocysteine sulfoximine), the most potent of a series of analogs of methionine sulfoximine… (More)
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