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Buthionine Sulfoximine

Known as: Buthionine Sulfoximine [Chemical/Ingredient], Butanoic Acid, 2-Amino-4-(S-butylsulfonimidoyl)-, S-(3-Amino-3-carboxypropyl)-S-butylsulfoximine 
A synthetic amino acid. Buthionine sulfoximine irreversibly inhibits gamma-glutamylcysteine synthase, thereby depleting cells of glutathione, a… Expand
National Institutes of Health

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Highly Cited
2015
Highly Cited
2015
BACKGROUND Recent genetic and morphologic studies have challenged the traditional view on the pathogenesis of ovarian cancer… Expand
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Highly Cited
2013
Highly Cited
2013
Present global warming is amplified in the Arctic and accompanied by unprecedented sea ice decline. Located along the main… Expand
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Highly Cited
2009
Highly Cited
2009
Summary Background Hysterectomy and bilateral salpingo-oophorectomy (BSO) is the standard surgery for stage I endometrial cancer… Expand
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Highly Cited
2008
Highly Cited
2008
The management of uterine sarcomas continues to present many difficulties. Primary surgery is the optimal treatment but the role… Expand
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Highly Cited
2004
Highly Cited
2004
AbstractClinical application of anticancer agents has been often hampered by toxicity against normal cells, so the achievement of… Expand
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Highly Cited
1999
Highly Cited
1999
The multidrug resistance protein MRP1 functions as an ATP-dependent conjugate export pump and confers multidrug resistance. We… Expand
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Highly Cited
1998
Highly Cited
1998
L-S,R-buthionine sulfoximine (L-S,R BSO) is a potent specific inhibitor of gamma-glutamylcysteine synthetase, the rate-limiting… Expand
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Highly Cited
1995
Highly Cited
1995
From 1969 to 1990, 649 patients with adenocarcinoma of the endometrium were surgically managed by gynecologic oncologists from… Expand
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Highly Cited
1985
Highly Cited
1985
Abstract The development of acquired resistance to antineoplastic drugs and the associated broad cross-resistance to other agents… Expand
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Highly Cited
1979
Highly Cited
1979
Buthionine sulfoximine (S-n-butyl homocysteine sulfoximine), the most potent of a series of analogs of methionine sulfoximine… Expand
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