Butadiene
National Institutes of Health
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Smoking-induced lung cancer is a major cause of cancer mortality in the US and worldwide. While 11-24 % of smokers will develop…
1,2,3,4-Diepoxybutane (DEB), a metabolite of the carcinogen butadiene, has been shown to cause glutathione (GSH)-dependent base…
In a follow-up study of mortality among North American synthetic rubber industry workers, cumulative exposure to 1,3-butadiene…
1,3-Butadiene is a known carcinogen and mutagen that acts through a variety of metabolic intermediates that react with DNA…
To determine the biological effects of specific DNA adducts resulting from the interaction of 1,3‐butadiene metabolites with DNA…
Measurement of specific adducts to hemoglobin can be used to establish the dosimetry of electrophilic compounds and metabolites…
Three metabolites of the industrial chemical 1,3‐butadiene (BD), namely butadiene monoepoxide (BMO, 3,4‐epoxy‐1‐butene…
1,3-Butadiene, a chemical produced in large volumes, induces cancer in many organs in rats (at 1000 and 8000 ppm) and mice (at 6…
Several studies of styrene-butadiene rubber (SBR) workers have reported excess cancers at various sites; however, little could be…