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Burimamide

Known as: Burimamide [Chemical/Ingredient], Thiourea, N-(4-(1H-imidazol-4-yl)butyl)-N'-methyl- 
An antagonist of histamine that appears to block both H2 and H3 histamine receptors. It has been used in the treatment of ulcers.
National Institutes of Health

Papers overview

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Highly Cited
1996
Highly Cited
1996
Histamine H2 receptors transfected in Chinese hamster ovary (CHO) cells are time- and dose-dependently upregulated upon exposure… 
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Highly Cited
1992
Highly Cited
1992
1 The effect of agents which interact with the histamine H3 receptor on potassium‐stimulated tritium release from slices of rat… 
Highly Cited
1987
Highly Cited
1987
The regulation of histamine synthesis was studied on rat brain slices or synaptosomes labeled with L-[3H]histidine… 
Highly Cited
1985
Highly Cited
1985
Regulation of histamine release was studied mainly on brain slices prelabeled with L-[3H]-histidine and depolarized by increased… 
Highly Cited
1978
Highly Cited
1978
Abstract The concept of two classes of histamine receptor, H 1 and H 2 , is introduced and the chemical derivation of histamine H… 
Highly Cited
1977
Highly Cited
1977
  • R. Rocklin
  • Journal of immunology
  • 1977
  • Corpus ID: 8452589
Histamine added in vitro to cultures of sensitized lymphocytes suppresses antigen-induced production of migration inhibitory… 
Highly Cited
1976
Highly Cited
1976
  • R. Rocklin
  • The Journal of clinical investigation
  • 1976
  • Corpus ID: 19662474
Histamine, one of the mediators involved in the IgE-mediated reaction, was demonstrated to influence in vivo and in vitro… 
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Highly Cited
1974
Highly Cited
1974
  • J. McNeill, S. Verma
  • The Journal of pharmacology and experimental…
  • 1974
  • Corpus ID: 32729840
Histamine and two histamine analogs, betazole and 3-(β-aminoethyl)-1,2,4-triazole (TD), increased cardiac contractility… 
Highly Cited
1973
Highly Cited
1973
  • P. Eyre
  • British journal of pharmacology
  • 1973
  • Corpus ID: 45518032
Histamine-induced relaxation of the sheep bronchus was antagonized by burimamide but not by mepyramine, indicating the presence… 
Highly Cited
1972
Highly Cited
1972
Abstract Burimamide is a new type of histamine antagonist; it blocks the H 2 -receptors involved not only in histamine-induced…