Burimamide

Known as: Burimamide [Chemical/Ingredient], Thiourea, N-(4-(1H-imidazol-4-yl)butyl)-N'-methyl- 
An antagonist of histamine that appears to block both H2 and H3 histamine receptors. It has been used in the treatment of ulcers.
National Institutes of Health

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Broader (2)

Anti-Ulcer AgentHistamine H2 Antagonists
In Bloodagonistsanalogs & derivativesantagonists & inhibitors
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Papers overview

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Highly Cited
1996
Highly Cited
1996
Inverse agonism of histamine H2 antagonist accounts for upregulation of spontaneously active histamine H2 receptors.
Histamine H2 receptors transfected in Chinese hamster ovary (CHO) cells are time- and dose-dependently upregulated upon exposure… (More)
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Highly Cited
1992
Highly Cited
1992
Histamine H3 receptors modulate the release of [3H]-acetylcholine from slices of rat entorhinal cortex: evidence for the possible existence of H3 receptor subtypes.
1. The effect of agents which interact with the histamine H3 receptor on potassium-stimulated tritium release from slices of rat… (More)
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Highly Cited
1989
Highly Cited
1989
Inhibition of noradrenaline release in the rat brain cortex via presynaptic H3 receptors
The effects of histamine and related drugs on the evoked tritium overflow from superfused rat brain cortex slices preincubated… (More)
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Highly Cited
1988
Highly Cited
1988
Histamine H3 receptor-mediated inhibition of serotonin release in the rat brain cortex
Rat brain cortex slices preincubated with 3H-serotonin were superfused with physiological salt solution (containing citalopram… (More)
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1976
1976
Blockade by burimamide of the restorative effect of histamine in tetrodotoxin-treated heart preparations.
1 In isolated heart preparations in which fast sodium channels were blocked by tetrodotoxin (2-4 x 10(-5) M), excitability was… (More)
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1976
1976
The pharmacology of burimamide and metiamide, two histamine H2-receptor antagonists.
Burimamide and metiamide are two histamine H2-receptor antagonists. Evidence is presented that indicates the competitive nature… (More)
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1975
1975
Electrophysiological effects of burimamide and 16,16-dimethyl prostaglandin E2 on the canine gastric mucosa.
The electrophysiological effects of two potent inhibitors of gastric acid secretion, burimamide and 16,16-dimethyl prostaglandin… (More)
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1973
1973
Histamine H2-receptors in the sheep bronchus and cat trachea: the action of burimamide.
Histamine-induced relaxation of the sheep bronchus was antagonized by burimamide but not by mepyramine, indicating the presence… (More)
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1973
1973
Specific inhibition by burimamide of histamine effects on myocardial contraction and cyclic AMP
1. In the isolated perfused guinea-pig heart, the increases in isotonic contraction and in cyclic AMP, produced by 2 μg of… (More)
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1973
1973
Anaphylaxis in the guinea-pig isolated heart: selective inhibition by burimamide of the positive inotropic and chronotropic effects of released histamine.
1. Anaphylaxis was induced in the isolated heart of the guinea-pig in the presence of burimamide at concentrations of 4 x 10(-5)M… (More)
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