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Burimamide

Known as: Burimamide [Chemical/Ingredient], Thiourea, N-(4-(1H-imidazol-4-yl)butyl)-N'-methyl- 
An antagonist of histamine that appears to block both H2 and H3 histamine receptors. It has been used in the treatment of ulcers.
National Institutes of Health

Related topics

Related topics

9 relations

Broader (2)

Anti-Ulcer AgentHistamine H2 Antagonists
In Bloodagonistsanalogs & derivativesantagonists & inhibitors
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Papers overview

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Highly Cited
2004
Highly Cited
2004
Histamine H3 receptor-mediated inhibition of serotonin release in the rat brain cortex
SummaryRat brain cortex slices preincubated with 3H-serotonin were superfused with physiological salt solution (containing… Expand
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Highly Cited
2001
Highly Cited
2001
Constitutive activity of histamine h(3) receptors stably expressed in SK-N-MC cells: display of agonism and inverse agonism by H(3) antagonists.
Agonist-independent activity of G-protein-coupled receptor, also referred to as constitutive activity, is a well-documented… Expand
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Highly Cited
1996
Highly Cited
1996
Inverse agonism of histamine H2 antagonist accounts for upregulation of spontaneously active histamine H2 receptors.
Histamine H2 receptors transfected in Chinese hamster ovary (CHO) cells are time- and dose-dependently upregulated upon exposure… Expand
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Highly Cited
1993
Highly Cited
1993
Cimetidine and other H2 receptor antagonists as powerful hydroxyl radical scavengers.
Hydroxyl radical scavengers are able to compete with deoxyribose for the hydroxyl radicals generated in a reaction mixture. We… Expand
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Highly Cited
1992
Highly Cited
1992
Histamine H3 receptors modulate the release of [3H]‐acetylcholine from slices of rat entorhinal cortex: evidence for the possible existence of H3 receptor subtypes
1 The effect of agents which interact with the histamine H3 receptor on potassium‐stimulated tritium release from slices of rat… Expand
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Highly Cited
1987
Highly Cited
1987
Autoinhibition of histamine synthesis mediated by presynaptic H3-receptors
The regulation of histamine synthesis was studied on rat brain slices or synaptosomes labeled with L-[3H]histidine… Expand
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Highly Cited
1985
Highly Cited
1985
Autoregulation of histamine release in brain by presynaptic H3-receptors
Regulation of histamine release was studied mainly on brain slices prelabeled with L-[3H]-histidine and depolarized by increased… Expand
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Review
1976
Review
1976
Pharmacology of sinomenine, an anti-rheumatic alkaloid from Sinomenium acutum.
The root and stem decoctions of Sinomenium acutum Rehd. et Wils. (formerly Sinomenium diversifolius Diels, one type of Fang-chi… Expand
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1973
1973
Histamine H2‐receptors in the sheep bronchus and cat trachea: the action of burimamide
  • P. Eyre
  • British journal of pharmacology
  • 1973
    • Corpus ID: 45518032
Histamine-induced relaxation of the sheep bronchus was antagonized by burimamide but not by mepyramine, indicating the presence… Expand
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1972
1972
Effects in man of histamine H 2 -receptor blockade by burimamide.
Abstract Burimamide is a new type of histamine antagonist; it blocks the H 2 -receptors involved not only in histamine-induced… Expand
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