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Burimamide

Known as: Burimamide [Chemical/Ingredient], Thiourea, N-(4-(1H-imidazol-4-yl)butyl)-N'-methyl- 
An antagonist of histamine that appears to block both H2 and H3 histamine receptors. It has been used in the treatment of ulcers.
National Institutes of Health

Related topics

Related topics

9 relations

Broader (2)

Anti-Ulcer AgentHistamine H2 Antagonists
In Bloodagonistsanalogs & derivativesantagonists & inhibitors
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Papers overview

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Highly Cited
1996
Highly Cited
1996
Inverse agonism of histamine H2 antagonist accounts for upregulation of spontaneously active histamine H2 receptors.
Histamine H2 receptors transfected in Chinese hamster ovary (CHO) cells are time- and dose-dependently upregulated upon exposure… 
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Highly Cited
1992
Highly Cited
1992
Histamine H3 receptors modulate the release of [3H]‐acetylcholine from slices of rat entorhinal cortex: evidence for the possible existence of H3 receptor subtypes
1 The effect of agents which interact with the histamine H3 receptor on potassium‐stimulated tritium release from slices of rat… 
Highly Cited
1987
Highly Cited
1987
Autoinhibition of histamine synthesis mediated by presynaptic H3-receptors
The regulation of histamine synthesis was studied on rat brain slices or synaptosomes labeled with L-[3H]histidine… 
Highly Cited
1985
Highly Cited
1985
Autoregulation of histamine release in brain by presynaptic H3-receptors
Regulation of histamine release was studied mainly on brain slices prelabeled with L-[3H]-histidine and depolarized by increased… 
Highly Cited
1978
Highly Cited
1978
Characterization and development of cimetidine as a histamine H2-receptor antagonist
Abstract The concept of two classes of histamine receptor, H 1 and H 2 , is introduced and the chemical derivation of histamine H… 
Highly Cited
1977
Highly Cited
1977
Histamine-induced suppressor factor (HSF): effect on migration inhibitory factor (MIF) production and proliferation.
  • R. Rocklin
  • Journal of immunology
  • 1977
  • Corpus ID: 8452589
Histamine added in vitro to cultures of sensitized lymphocytes suppresses antigen-induced production of migration inhibitory… 
Highly Cited
1976
Highly Cited
1976
Modulation of cellular-immune responses in vivo and in vitro by histamine receptor-bearing lymphocytes.
  • R. Rocklin
  • The Journal of clinical investigation
  • 1976
  • Corpus ID: 19662474
Histamine, one of the mediators involved in the IgE-mediated reaction, was demonstrated to influence in vivo and in vitro… 
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Highly Cited
1974
Highly Cited
1974
Blockade by burimamide of the effects of histamine and histamine analogs on cardiac contractility, phosphorylase activation and cyclic adenosine monophosphate.
  • J. McNeill, S. Verma
  • The Journal of pharmacology and experimental…
  • 1974
  • Corpus ID: 32729840
Histamine and two histamine analogs, betazole and 3-(β-aminoethyl)-1,2,4-triazole (TD), increased cardiac contractility… 
Highly Cited
1973
Highly Cited
1973
Histamine H2‐receptors in the sheep bronchus and cat trachea: the action of burimamide
  • P. Eyre
  • British journal of pharmacology
  • 1973
  • Corpus ID: 45518032
Histamine-induced relaxation of the sheep bronchus was antagonized by burimamide but not by mepyramine, indicating the presence… 
Highly Cited
1972
Highly Cited
1972
Effects in man of histamine H 2 -receptor blockade by burimamide.
Abstract Burimamide is a new type of histamine antagonist; it blocks the H 2 -receptors involved not only in histamine-induced… 
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