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Buprenorphine

Known as: 21-Cyclopropyl-7alpha-[(S)-1-hydroxy-1,2,2-trimethylpropyl]-6,14-endo-ethano-6,7,8,14-tetrahydrooripavine, 6,14-Ethenomorphinan-7-methanol, 17-(cyclopropylmethyl)-alpha-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha-methyl-, (5alpha,7alpha(S))-, Buprenorphine [Chemical/Ingredient] 
A derivative of the opioid alkaloid THEBAINE that is a more potent and longer lasting analgesic than MORPHINE. It appears to act as a partial agonist… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2016
Review
2016
IMPORTANCE Primary care clinicians find managing chronic pain challenging. Evidence of long-term efficacy of opioids for chronic… Expand
Review
2014
Review
2014
BACKGROUND Buprenorphine maintenance treatment has been evaluated in randomised controlled trials against placebo medication, and… Expand
Highly Cited
2010
Highly Cited
2010
BACKGROUND Methadone, a full mu-opioid agonist, is the recommended treatment for opioid dependence during pregnancy. However… Expand
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Review
2007
Review
2007
OBJECTIVES To assess the clinical effectiveness and cost-effectiveness of buprenorphine maintenance therapy (BMT) and methadone… Expand
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Review
2004
Review
2004
BACKGROUND Buprenorphine has recently been reported to be an alternative to methadone and LAAM for maintenance treatment of… Expand
Highly Cited
2003
Highly Cited
2003
BACKGROUND Office-based treatment of opiate addiction with a sublingual-tablet formulation of buprenorphine and naloxone has been… Expand
Highly Cited
1994
Highly Cited
1994
The purpose of this study was to characterize the acute effects of buprenorphine, an opioid partial (μ‐agonist, across a wide… Expand
Highly Cited
1992
Highly Cited
1992
OBJECTIVE To assess the efficacy of buprenorphine for short-term maintenance/detoxification. DESIGN A randomized, double-blind… Expand
Highly Cited
1978
Highly Cited
1978
Buprenorphine was evaluated for its abuse potential and utility in treating narcotic addiction. The drug was morphine-like but… Expand
Highly Cited
1977
Highly Cited
1977
1 Buprenorphine is a highly lipophilic derivative of oripavine. In rodent antinociceptive assays (writhing, tail pressure… Expand