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Buprenorphine

Known as: 21-Cyclopropyl-7alpha-[(S)-1-hydroxy-1,2,2-trimethylpropyl]-6,14-endo-ethano-6,7,8,14-tetrahydrooripavine, 6,14-Ethenomorphinan-7-methanol, 17-(cyclopropylmethyl)-alpha-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha-methyl-, (5alpha,7alpha(S))-, Buprenorphine [Chemical/Ingredient] 
A derivative of the opioid alkaloid THEBAINE that is a more potent and longer lasting analgesic than MORPHINE. It appears to act as a partial agonist… Expand
National Institutes of Health

Papers overview

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Review
2019
Review
2019
Medication treatment (MT) is one of the few evidence-based strategies proposed to combat the current opioid epidemic. We examined… Expand
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Review
2019
Review
2019
ABSTRACT Amid worsening opioid overdose death rates, the nation continues to face a persistent addiction treatment gap limiting… Expand
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Review
2018
Review
2018
The opioid epidemic has been called the "most consequential preventable public health problem in the United States." Though there… Expand
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Highly Cited
2010
Highly Cited
2010
BACKGROUND Methadone, a full mu-opioid agonist, is the recommended treatment for opioid dependence during pregnancy. However… Expand
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Highly Cited
2003
Highly Cited
2003
BACKGROUND Office-based treatment of opiate addiction with a sublingual-tablet formulation of buprenorphine and naloxone has been… Expand
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Highly Cited
2000
Highly Cited
2000
BACKGROUND Opioid dependence is a chronic, relapsing disorder with important public health implications. METHODS In a 17-week… Expand
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Highly Cited
1995
Highly Cited
1995
Opiates were used to treat major depression until the mid-1950s. The advent of opioids with mixed agonist-antagonist or partial… Expand
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Highly Cited
1994
Highly Cited
1994
The purpose of this study was to characterize the acute effects of buprenorphine, an opioid partial (μ‐agonist, across a wide… Expand
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Highly Cited
1978
Highly Cited
1978
Buprenorphine was evaluated for its abuse potential and utility in treating narcotic addiction. The drug was morphine-like but… Expand
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Highly Cited
1977
Highly Cited
1977
1 Buprenorphine is a highly lipophilic derivative of oripavine. In rodent antinociceptive assays (writhing, tail pressure… Expand
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