Buprenorphine

Known as: 21-Cyclopropyl-7alpha-[(S)-1-hydroxy-1,2,2-trimethylpropyl]-6,14-endo-ethano-6,7,8,14-tetrahydrooripavine, 6,14-Ethenomorphinan-7-methanol, 17-(cyclopropylmethyl)-alpha-(1,1-dimethylethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha-methyl-, (5alpha,7alpha(S))-, Buprenorphine [Chemical/Ingredient] 
A derivative of the opioid alkaloid THEBAINE that is a more potent and longer lasting analgesic than MORPHINE. It appears to act as a partial agonist… (More)
National Institutes of Health

Papers overview

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Review
2017
Review
2017
Objective To compare the risk for all cause and overdose mortality in people with opioid dependence during and after substitution… (More)
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Highly Cited
2010
Highly Cited
2010
BACKGROUND Methadone, a full mu-opioid agonist, is the recommended treatment for opioid dependence during pregnancy. However… (More)
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Highly Cited
2008
Highly Cited
2008
SUMMARY OF CONSENSUS: 1. The use of opioids in cancer pain: The criteria for selecting analgesics for pain treatment in the… (More)
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Review
2005
Review
2005
New effective analgesics are needed for the treatment of pain. Buprenorphine, a partial mu-opioid agonist which has been in… (More)
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Highly Cited
2000
Highly Cited
2000
BACKGROUND Opioid dependence is a chronic, relapsing disorder with important public health implications. METHODS In a 17-week… (More)
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Highly Cited
1995
Highly Cited
1995
Opiates were used to treat major depression until the mid-1950s. The advent of opioids with mixed agonist-antagonist or partial… (More)
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Highly Cited
1993
Highly Cited
1993
Buprenorphine at 2 mg and 6 mg daily was compared with methadone at 35 mg and 65 mg during 24 weeks of maintenance among 125… (More)
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Highly Cited
1992
Highly Cited
1992
OBJECTIVE To assess the efficacy of buprenorphine for short-term maintenance/detoxification. DESIGN A randomized, double-blind… (More)
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Highly Cited
1980
Highly Cited
1980
Heroin-dependent men were given buprenorphine (a partial opiate agonist-antagonist) or a placebo under duoble-blind conditions on… (More)
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Highly Cited
1978
Highly Cited
1978
Buprenorphine was evaluated for its abuse potential and utility in treating narcotic addiction. The drug was morphine-like but… (More)
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