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Brivudine Phosphoramidate
Known as:
(E)-5-(2-Bromovinyl)-2'-deoxy-5'-uridyl Phenyl L-methoxyalaninylphosphoramidate
, BVDU Prodrug
, BVdU Phosphoramidate
A small molecule phosphoramidate derivative of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVdU) with potential antineoplastic activity. Selectively active…
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National Institutes of Health
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Broader (1)
NB1011
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2009
Review
2009
Aryloxy Phosphoramidate Triesters: a Technology for Delivering Monophosphorylated Nucleosides and Sugars into Cells
Y. Mehellou
,
J. Balzarini
,
C. Mcguigan
ChemMedChem
2009
Corpus ID: 196857882
Prodrug technologies aimed at delivering nucleoside monophosphates into cells (protides) have proved to be effective in improving…
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Highly Cited
2008
Highly Cited
2008
Potent and highly selective hypoxia-activated achiral phosphoramidate mustards as anticancer drugs.
Jianxin Duan
,
H. Jiao
,
+14 authors
M. Matteucci
Journal of Medicinal Chemistry
2008
Corpus ID: 10261472
A series of achiral hypoxia-activated prodrugs were synthesized on the basis of the DNA cross-linking toxin of the prodrug…
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Highly Cited
2007
Highly Cited
2007
Phosphoramidate pronucleotides: a comparison of the phosphoramidase substrate specificity of human and Escherichia coli histidine triad nucleotide binding proteins.
T. Chou
,
J. Baraniak
,
+4 authors
C. Wagner
Molecular Pharmaceutics
2007
Corpus ID: 12021189
To facilitate the delivery of nucleotide-based therapeutics to cells and tissues, a variety of pronucleotide approaches have been…
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Review
2004
Review
2004
Aryloxy phosphoramidate triesters as pro-tides.
D. Cahard
,
C. Mcguigan
,
J. Balzarini
Mini-Reviews in Medical Chemistry
2004
Corpus ID: 34345595
We herein describe the development of aryloxy phosphoramidate triesters as an effective pro-tide motif for the intracellular…
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Highly Cited
2001
Highly Cited
2001
Phosphoramidate oligonucleotides as potent antisense molecules in cells and in vivo
M. Faria
,
D. Spiller
,
+5 authors
C. Giovannangeli
Nature Biotechnology
2001
Corpus ID: 35729129
Antisense oligonucleotides are designed to specifically hybridize to a target messenger RNA (mRNA) and interfere with the…
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Highly Cited
2000
Highly Cited
2000
Targeted inhibition of transcription elongation in cells mediated by triplex-forming oligonucleotides.
M. Faria
,
C. Wood
,
+5 authors
C. Giovannangeli
Proceedings of the National Academy of Sciences…
2000
Corpus ID: 19926027
Triple-helix-forming oligonucleotides (TFOs) bind in the major groove of double-stranded DNA at oligopyrimidine small middle…
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Highly Cited
1997
Highly Cited
1997
Accessibility of nuclear DNA to triplex-forming oligonucleotides: the integrated HIV-1 provirus as a target.
C. Giovannangeli
,
S. Diviacco
,
V. Labrousse
,
S. Gryaznov
,
P. Charneau
,
C. Hélène
Proceedings of the National Academy of Sciences…
1997
Corpus ID: 34420587
The control of gene transcription by antigene oligonucleotides rests upon the specific recognition of double-helical DNA by…
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Highly Cited
1997
Highly Cited
1997
Antileukemia effect of c-myc N3'-->P5' phosphoramidate antisense oligonucleotides in vivo.
T. Skorski
,
D. Perrotti
,
M. Nieborowska-Skorska
,
S. Gryaznov
,
B. Calabretta
Proceedings of the National Academy of Sciences…
1997
Corpus ID: 1934562
In vitro, uniformly modified oligonucleotide N3'-->P5' phosphoramidates are apparently more potent antisense agents than…
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Highly Cited
1995
Highly Cited
1995
Synthesis of oligodeoxyribonucleotide N3'-->P5' phosphoramidates.
J. Chen
,
R. Schultz
,
D. Lloyd
,
S. Gryaznov
Nucleic Acids Research
1995
Corpus ID: 23237635
An efficient synthesis of the novel nucleic acid analogs oligodeoxyribonucleotide N3'-->P5' phosphoramidates, where the 3'-oxygen…
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Highly Cited
1977
Highly Cited
1977
Agrocin 84 is a 6-N-phosphoramidate of an adenine nucleotide analogue
W. Roberts
,
M. Tate
,
A. Kerr
Nature
1977
Corpus ID: 4270107
WE wish to draw attention to the natural occurrence of an extraordinarily selective antibiotic, agrocin 84, which is a…
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