Brivudine Phosphoramidate

Known as: (E)-5-(2-Bromovinyl)-2'-deoxy-5'-uridyl Phenyl L-methoxyalaninylphosphoramidate, BVDU Prodrug, BVdU Phosphoramidate 
A small molecule phosphoramidate derivative of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVdU) with potential antineoplastic activity. Selectively active… (More)
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

NB1011

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
Potent and highly selective hypoxia-activated achiral phosphoramidate mustards as anticancer drugs.
A series of achiral hypoxia-activated prodrugs were synthesized on the basis of the DNA cross-linking toxin of the prodrug… (More)
  • figure 1
  • table 1
  • figure 3
  • table 2
  • figure 4
Is this relevant?
2006
2006
Characterization of modified antisense oligonucleotides in Xenopus laevis embryos.
A wide variety of modified oligonucleotides have been tested as antisense agents. Each chemical modification produces a distinct… (More)
  • figure 2
  • table 2
  • figure 3
  • figure 4
  • table 3
Is this relevant?
2005
2005
31P NMR and genetic analysis establish hinT as the only Escherchia coli purine nucleoside phosphoramidase and as essential for growth under high salt conditions.
Eukaryotic cells encode AMP-lysine (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester) 5'-phosphoramidate) hydrolases related to… (More)
  • figure 1
  • figure 2
  • table I
  • figure 3
  • figure 4
Is this relevant?
2003
2003
A potent and specific morpholino antisense inhibitor of hepatitis C translation in mice.
Hepatitis C virus (HCV) is an RNA virus infecting one in every 40 people worldwide. Current treatments are ineffective and HCV is… (More)
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
2001
2001
Phosphoramidate oligonucleotides as potent antisense molecules in cells and in vivo
Antisense oligonucleotides are designed to specifically hybridize to a target messenger RNA (mRNA) and interfere with the… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2000
2000
Targeted inhibition of transcription elongation in cells mediated by triplex-forming oligonucleotides.
Triple-helix-forming oligonucleotides (TFOs) bind in the major groove of double-stranded DNA at oligopyrimidine small middle… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
2000
2000
Unambiguous demonstration of triple-helix-directed gene modification.
Triple-helix-forming oligonucleotides (TFOs), which can potentially modify target genes irreversibly, represent promising tools… (More)
Is this relevant?
1997
1997
Accessibility of nuclear DNA to triplex-forming oligonucleotides: the integrated HIV-1 provirus as a target.
The control of gene transcription by antigene oligonucleotides rests upon the specific recognition of double-helical DNA by… (More)
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
1997
1997
Antileukemia effect of c-myc N3'-->P5' phosphoramidate antisense oligonucleotides in vivo.
In vitro, uniformly modified oligonucleotide N3'-->P5' phosphoramidates are apparently more potent antisense agents than… (More)
Is this relevant?
1977
1977
Agrocin 84 is a 6-N-phosphoramidate of an adenine nucleotide analogue
WE wish to draw attention to the natural occurrence of an extraordinarily selective antibiotic, agrocin 84, which is a… (More)
Is this relevant?