Brivudine Phosphoramidate

Known as: (E)-5-(2-Bromovinyl)-2'-deoxy-5'-uridyl Phenyl L-methoxyalaninylphosphoramidate, BVDU Prodrug, BVdU Phosphoramidate 
A small molecule phosphoramidate derivative of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVdU) with potential antineoplastic activity. Selectively active… (More)
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
A series of achiral hypoxia-activated prodrugs were synthesized on the basis of the DNA cross-linking toxin of the prodrug… (More)
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2006
2006
A wide variety of modified oligonucleotides have been tested as antisense agents. Each chemical modification produces a distinct… (More)
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2005
2005
Eukaryotic cells encode AMP-lysine (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester) 5'-phosphoramidate) hydrolases related to… (More)
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2003
2003
Hepatitis C virus (HCV) is an RNA virus infecting one in every 40 people worldwide. Current treatments are ineffective and HCV is… (More)
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2001
2001
Antisense oligonucleotides are designed to specifically hybridize to a target messenger RNA (mRNA) and interfere with the… (More)
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2000
2000
Triple-helix-forming oligonucleotides (TFOs) bind in the major groove of double-stranded DNA at oligopyrimidine small middle… (More)
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2000
2000
Triple-helix-forming oligonucleotides (TFOs), which can potentially modify target genes irreversibly, represent promising tools… (More)
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1997
1997
The control of gene transcription by antigene oligonucleotides rests upon the specific recognition of double-helical DNA by… (More)
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1997
1997
In vitro, uniformly modified oligonucleotide N3'-->P5' phosphoramidates are apparently more potent antisense agents than… (More)
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1977
1977
WE wish to draw attention to the natural occurrence of an extraordinarily selective antibiotic, agrocin 84, which is a… (More)
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