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Brivudine Phosphoramidate

Known as: (E)-5-(2-Bromovinyl)-2'-deoxy-5'-uridyl Phenyl L-methoxyalaninylphosphoramidate, BVDU Prodrug, BVdU Phosphoramidate 
A small molecule phosphoramidate derivative of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVdU) with potential antineoplastic activity. Selectively active… 
National Institutes of Health

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NB1011

Papers overview

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Review
2009
Review
2009
Aryloxy Phosphoramidate Triesters: a Technology for Delivering Monophosphorylated Nucleosides and Sugars into Cells
Prodrug technologies aimed at delivering nucleoside monophosphates into cells (protides) have proved to be effective in improving… 
Highly Cited
2008
Highly Cited
2008
Potent and highly selective hypoxia-activated achiral phosphoramidate mustards as anticancer drugs.
A series of achiral hypoxia-activated prodrugs were synthesized on the basis of the DNA cross-linking toxin of the prodrug… 
Highly Cited
2007
Highly Cited
2007
Phosphoramidate pronucleotides: a comparison of the phosphoramidase substrate specificity of human and Escherichia coli histidine triad nucleotide binding proteins.
To facilitate the delivery of nucleotide-based therapeutics to cells and tissues, a variety of pronucleotide approaches have been… 
Review
2004
Review
2004
Aryloxy phosphoramidate triesters as pro-tides.
We herein describe the development of aryloxy phosphoramidate triesters as an effective pro-tide motif for the intracellular… 
Highly Cited
2001
Highly Cited
2001
Phosphoramidate oligonucleotides as potent antisense molecules in cells and in vivo
Antisense oligonucleotides are designed to specifically hybridize to a target messenger RNA (mRNA) and interfere with the… 
Highly Cited
2000
Highly Cited
2000
Targeted inhibition of transcription elongation in cells mediated by triplex-forming oligonucleotides.
Triple-helix-forming oligonucleotides (TFOs) bind in the major groove of double-stranded DNA at oligopyrimidine small middle… 
Highly Cited
1997
Highly Cited
1997
Accessibility of nuclear DNA to triplex-forming oligonucleotides: the integrated HIV-1 provirus as a target.
The control of gene transcription by antigene oligonucleotides rests upon the specific recognition of double-helical DNA by… 
Highly Cited
1997
Highly Cited
1997
Antileukemia effect of c-myc N3'-->P5' phosphoramidate antisense oligonucleotides in vivo.
In vitro, uniformly modified oligonucleotide N3'-->P5' phosphoramidates are apparently more potent antisense agents than… 
Highly Cited
1995
Highly Cited
1995
Synthesis of oligodeoxyribonucleotide N3'-->P5' phosphoramidates.
An efficient synthesis of the novel nucleic acid analogs oligodeoxyribonucleotide N3'-->P5' phosphoramidates, where the 3'-oxygen… 
Highly Cited
1977
Highly Cited
1977
Agrocin 84 is a 6-N-phosphoramidate of an adenine nucleotide analogue
WE wish to draw attention to the natural occurrence of an extraordinarily selective antibiotic, agrocin 84, which is a… 
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