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Brivudine Phosphoramidate

Known as: (E)-5-(2-Bromovinyl)-2'-deoxy-5'-uridyl Phenyl L-methoxyalaninylphosphoramidate, BVDU Prodrug, BVdU Phosphoramidate 
A small molecule phosphoramidate derivative of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVdU) with potential antineoplastic activity. Selectively active… Expand
National Institutes of Health

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NB1011

Papers overview

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Highly Cited
2008
Highly Cited
2008
Potent and highly selective hypoxia-activated achiral phosphoramidate mustards as anticancer drugs.
A series of achiral hypoxia-activated prodrugs were synthesized on the basis of the DNA cross-linking toxin of the prodrug… Expand
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Highly Cited
2007
Highly Cited
2007
Phosphoramidate pronucleotides: a comparison of the phosphoramidase substrate specificity of human and Escherichia coli histidine triad nucleotide binding proteins.
To facilitate the delivery of nucleotide-based therapeutics to cells and tissues, a variety of pronucleotide approaches have been… Expand
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Highly Cited
2001
Highly Cited
2001
Phosphoramidate oligonucleotides as potent antisense molecules in cells and in vivo
Antisense oligonucleotides are designed to specifically hybridize to a target messenger RNA (mRNA) and interfere with the… Expand
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Highly Cited
2000
Highly Cited
2000
Targeted inhibition of transcription elongation in cells mediated by triplex-forming oligonucleotides.
Triple-helix-forming oligonucleotides (TFOs) bind in the major groove of double-stranded DNA at oligopyrimidine small middle… Expand
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Highly Cited
1997
Highly Cited
1997
Accessibility of nuclear DNA to triplex-forming oligonucleotides: the integrated HIV-1 provirus as a target.
The control of gene transcription by antigene oligonucleotides rests upon the specific recognition of double-helical DNA by… Expand
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Highly Cited
1997
Highly Cited
1997
Antileukemia effect of c-myc N3'-->P5' phosphoramidate antisense oligonucleotides in vivo.
In vitro, uniformly modified oligonucleotide N3'-->P5' phosphoramidates are apparently more potent antisense agents than… Expand
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Highly Cited
1996
Highly Cited
1996
Stable triple helices formed by oligonucleotide N3'-->P5' phosphoramidates inhibit transcription elongation.
Oligonucleotide analogs with N3'-->P5' phosphoramidate linkages bind to the major groove of double-helical DNA at specific… Expand
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Highly Cited
1995
Highly Cited
1995
Synthesis of oligodeoxyribonucleotide N3'-->P5' phosphoramidates.
An efficient synthesis of the novel nucleic acid analogs oligodeoxyribonucleotide N3'-->P5' phosphoramidates, where the 3'-oxygen… Expand
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Highly Cited
1991
Highly Cited
1991
Synthesis and anti-HIV activity of some haloalkyl phosphoramidate derivatives of 3'-azido-3'-deoxythymidine (AZT): potent activity of the trichloroethyl methoxyalaninyl compound.
Phosphate triester derivatives of AZT have been prepared as membrane-soluble pro-drugs of the bio-active nucleotides, and have… Expand
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Highly Cited
1977
Highly Cited
1977
Agrocin 84 is a 6-N-phosphoramidate of an adenine nucleotide analogue
WE wish to draw attention to the natural occurrence of an extraordinarily selective antibiotic, agrocin 84, which is a… Expand
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