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Brivudine Phosphoramidate

Known as: (E)-5-(2-Bromovinyl)-2'-deoxy-5'-uridyl Phenyl L-methoxyalaninylphosphoramidate, BVDU Prodrug, BVdU Phosphoramidate 
A small molecule phosphoramidate derivative of (E)-5-(2-bromovinyl)-2'-deoxyuridine (BVdU) with potential antineoplastic activity. Selectively active… 
National Institutes of Health

Papers overview

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Review
2009
Review
2009
Prodrug technologies aimed at delivering nucleoside monophosphates into cells (protides) have proved to be effective in improving… 
Highly Cited
2008
Highly Cited
2008
A series of achiral hypoxia-activated prodrugs were synthesized on the basis of the DNA cross-linking toxin of the prodrug… 
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Highly Cited
2007
Highly Cited
2007
To facilitate the delivery of nucleotide-based therapeutics to cells and tissues, a variety of pronucleotide approaches have been… 
Review
2004
Review
2004
We herein describe the development of aryloxy phosphoramidate triesters as an effective pro-tide motif for the intracellular… 
Highly Cited
2001
Highly Cited
2001
Antisense oligonucleotides are designed to specifically hybridize to a target messenger RNA (mRNA) and interfere with the… 
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Highly Cited
2000
Highly Cited
2000
Triple-helix-forming oligonucleotides (TFOs) bind in the major groove of double-stranded DNA at oligopyrimidine small middle… 
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Highly Cited
1997
Highly Cited
1997
The control of gene transcription by antigene oligonucleotides rests upon the specific recognition of double-helical DNA by… 
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Highly Cited
1996
Highly Cited
1996
Oligonucleotide analogs with N3'-->P5' phosphoramidate linkages bind to the major groove of double-helical DNA at specific… 
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Highly Cited
1995
Highly Cited
1995
An efficient synthesis of the novel nucleic acid analogs oligodeoxyribonucleotide N3'-->P5' phosphoramidates, where the 3'-oxygen… 
Highly Cited
1977
Highly Cited
1977
WE wish to draw attention to the natural occurrence of an extraordinarily selective antibiotic, agrocin 84, which is a…