Bisulfite Sequencing

A DNA sequencing technique that can differentiate cytosine from 5-methylcytosine in a DNA sample. First, a denatured DNA sample is treated with… (More)
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
We report a single-cell bisulfite sequencing (scBS-seq) method that can be used to accurately measure DNA methylation at up to 48… (More)
  • figure 1
  • figure 2
Is this relevant?
Highly Cited
2011
Highly Cited
2011
Genome-wide mapping of 5-methylcytosine is of broad interest to many fields of biology and medicine. A variety of methods have… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2010
Highly Cited
2010
BACKGROUND We recently showed that enzymes of the TET family convert 5-mC to 5-hydroxymethylcytosine (5-hmC) in DNA. 5-hmC is… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2009
Highly Cited
2009
Current DNA methylation assays are limited in the flexibility and efficiency of characterizing a large number of genomic targets… (More)
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
2009
Highly Cited
2009
Bisulfite sequencing is a powerful technique to study DNA cytosine methylation. Bisulfite treatment followed by PCR amplification… (More)
  • table 1
  • table 2
Is this relevant?
Highly Cited
2009
Highly Cited
2009
Bisulfite sequencing using next generation sequencers yields genome-wide measurements of DNA methylation at single nucleotide… (More)
  • table 1
Is this relevant?
Highly Cited
2009
Highly Cited
2009
DNA methylation is a critical epigenetic mark that is essential for mammalian development and aberrant in many diseases including… (More)
Is this relevant?
Highly Cited
2008
Highly Cited
2008
Covalent modifications of nucleic acids play an important role in regulating their functions. Among these modifications… (More)
Is this relevant?
Highly Cited
2005
Highly Cited
2005
We describe a large-scale random approach termed reduced representation bisulfite sequencing (RRBS) for analyzing and comparing… (More)
  • figure 1
  • figure 2
  • figure 3
  • table 1
  • figure 4
Is this relevant?
Highly Cited
2005
Highly Cited
2005
SUMMARY Manual processing of DNA methylation data from bisulfite sequencing is a tedious and error-prone task. Here we present an… (More)
Is this relevant?