Bisbenzimidazole

Known as: 4-(5-(5-(4-Methylpiperazin-1-yl)benzimidazol-2- yl)benzimidazol-2-yl)phenol, Pibenzimol Hydrocholoride, Pibenzimol Hydrochloride 
A fluorescent dye of benzimidazole derivative. Pibenzimol binds to AT-specific sites in the minor groove of duplex DNA and inhibits topoisomerase I… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1970-2017
0246819702017

Papers overview

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2015
2015
Cancer is a leading cause of death in developed countries and second cause in developing countries. Herein we are reporting the… (More)
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2003
2003
DNA minor groove binders, Hoechst 33258 and Hoechst 33342, have been reported to protect against radiation-induced DNA-strand… (More)
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2001
2001
The synthesis and evaluation of the novel head-to-head bisbenzimidazole compound 2,2-bis[4'-(3' '-dimethylamino-1' '-propyloxy… (More)
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2000
2000
PURPOSE The DNA-minor-groove-ligands bisbenzimidazoles Hoechst 33258 and 33342 have been reported to protect against radiation… (More)
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Highly Cited
1992
Highly Cited
1992
Mouse thymocytes readily undergo apoptosis-associated DNA degradation upon exposure to glucocorticoids or ionizing radiation. It… (More)
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Highly Cited
1990
Highly Cited
1990
A simple assay is described using bisbenzimidazole (Hoechst 33258) to determine cellular DNA content in 96-well tissue cultures… (More)
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1990
1990
Analogues of the phenylbisbenzimidazole dye pibenzimol bind tightly to the minor groove of DNA. A clonogenic assay has been used… (More)
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Highly Cited
1988
Highly Cited
1988
A simple two-step fluorometric assay of DNA in cartilage explants, utilizing the bisbenzimidazole dye Hoechst 33258, is described… (More)
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Highly Cited
1983
Highly Cited
1983
The validation of a simple and rapid DNA solubilization procedure is described. Quantitative extraction of intact, polymerized… (More)
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Highly Cited
1976
Highly Cited
1976
Absorption, fluroescence and circular dichroism measrements on 33258 Hoechst-deoxyribonucleic acid (DNA) complexes are consistent… (More)
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