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Bisbenzimidazole

Known as: 4-(5-(5-(4-Methylpiperazin-1-yl)benzimidazol-2- yl)benzimidazol-2-yl)phenol, PIBENZIMOL, Pibenzimol Hydrocholoride 
A fluorescent dye of benzimidazole derivative. Pibenzimol binds to AT-specific sites in the minor groove of duplex DNA and inhibits topoisomerase I… Expand
National Institutes of Health

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Highly Cited
2004
Highly Cited
2004
The interaction of the bisbenzimidazole dye 33258 Hoechst with DNA and chromatin is characterized by changes in absorption… Expand
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2001
2001
The synthesis and evaluation of the novel head-to-head bisbenzimidazole compound 2,2-bis[4'-(3' '-dimethylamino-1' '-propyloxy… Expand
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Highly Cited
1992
Highly Cited
1992
Mouse thymocytes readily undergo apoptosis-associated DNA degradation upon exposure to glucocorticoids or ionizing radiation. It… Expand
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Highly Cited
1990
Highly Cited
1990
A simple assay is described using bisbenzimidazole (Hoechst 33258) to determine cellular DNA content in 96-well tissue cultures… Expand
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Highly Cited
1988
Highly Cited
1988
A simple two-step fluorometric assay of DNA in cartilage explants, utilizing the bisbenzimidazole dye Hoechst 33258, is described… Expand
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Highly Cited
1983
Highly Cited
1983
The validation of a simple and rapid DNA solubilization procedure is described. Quantitative extraction of intact, polymerized… Expand
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Highly Cited
1980
Highly Cited
1980
Abstract A simple and rapid assay for quantitative determinations of DNA in crude homogenates is described. The method is based… Expand
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Highly Cited
1979
Highly Cited
1979
Abstract The DNA concentration of a crude cellular homogenate can be measured accurately in the nanogram range using the… Expand
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Highly Cited
1976
Highly Cited
1976
Absorption, fluroescence and circular dichroism measrements on 33258 Hoechst-deoxyribonucleic acid (DNA) complexes are consistent… Expand
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Highly Cited
1974
Highly Cited
1974
  • Samuel A. Latt
  • Proceedings of the National Academy of Sciences…
  • 1974
  • Corpus ID: 19627732
Sister chromatid exchanges in chromosomes from human lymphocytes grown two replication cycles in medium containing 5… Expand
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