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Bisbenzimidazole

Known as: 4-(5-(5-(4-Methylpiperazin-1-yl)benzimidazol-2- yl)benzimidazol-2-yl)phenol, PIBENZIMOL, Pibenzimol Hydrocholoride 
A fluorescent dye of benzimidazole derivative. Pibenzimol binds to AT-specific sites in the minor groove of duplex DNA and inhibits topoisomerase I… 
National Institutes of Health

Related topics

Related topics

15 relations

Narrower (5)

Bisbenzimidazole TrihydrochlorideH.A.-yellowHoe 43254Hoechst 33258

Broader (2)

FilaricidesFluorescent Dyes
In BloodNCIt Antineoplastic Agent Terminologyagonistsanalogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Symmetrical bisbenzimidazoles with benzenediyl spacer: the role of the shape of the ligand on the stabilization and structural alterations in telomeric G-quadruplex DNA and telomerase inhibition.
The extremities of chromosomes end in a G-rich single-stranded overhang that has been implicated in the onset of the replicate… 
2008
2008
Study of the factors affecting the photoelectrode characteristics of a perylene/phthalocyanine bilayer working in the water phase.
Some types of phthalocyanines (MPc (M = H(2), Cu, or Zn), a p-type semiconductor) were used in combination with 3,4,9,10… 
2005
2005
Fluorescence spectroscopic studies to characterize the internal environment of tetraethyl-orthosilicate derived sol-gel bulk and thin films with aging.
2004
2004
DNA ligand Hoechst-33342 enhances UV induced cytotoxicity in human glioma cell lines.
Highly Cited
2001
Highly Cited
2001
Synthesis, crystal structure, spectral studies, and catechol oxidase activity of trigonal bipyramidal Cu(II) complexes derived from a tetradentate diamide bisbenzimidazole ligand.
A new benzimidazole-based diamide ligand-N,N'-bis(glycine-2- benzimidazolyl)hexanediamide (GBHA)-has been synthesized and… 
2001
2001
Double-stranded DNA binding characteristics and subcellular distribution of a minor groove binding diphenyl ether bisbenzimidazole.
The interactions of Hoechst 33377 (H1) with 20 different oligomeric duplexes have been investigated via spectrofluorometric… 
1994
1994
In vitro stimulation of insulin release by SL 84.0418, a new alpha 2-adrenoceptor antagonist.
Highly Cited
1993
Highly Cited
1993
The different binding modes of Hoechst 33258 to DNA studied by electric linear dichroism.
The binding mode of the bisbenzimidazole derivative Hoechst 33258 to a series of DNAs and polynucleotides has been investigated… 
1991
1991
Phase II study of pibenzimol in pancreatic cancer
SummaryTwenty-three patients with advanced pancreatic adenocarcinoma were treated with Pibenzimol utilizing a daily intravenous… 
Highly Cited
1977
Highly Cited
1977
Fluorometric detection of deoxyribonucleic acid synthesis; possibilities for interfacing bromodeoxyuridine dye techniques with flow fluorometry.
Fluorometric detection of the biosynthetic incorporation of 5-bromodeoxyuridine (BrdU) into deoxyribonucleic acid has permitted… 
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