Bioreductive Agent

Known as: Hypoxic Cell Sensitizer, Hypoxic Cell Cytotoxic Agent, Selective Hypoxic Cell Cytotoxic Agent 
Antitumor agents that are activated by biological reduction and have selective efficacy against hypoxic solid tumors. (NCI)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1975-2018
051019752018

Papers overview

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2014
2014
PURPOSE This prospective, randomized phase III intergroup trial of the Gynecologic Oncology Group and National Cancer Institute… (More)
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2011
2011
We describe novel composite nanoparticles consisting of a gold-silver nanocage core and a mesoporous silica shell functionalized… (More)
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2010
2010
PURPOSE To evaluate the effect of tumor hypoxia on the expected level of cell killing by regimens of stereotactic ablative… (More)
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2003
2003
The bioreductive drug, AQ4N, is metabolized under hypoxic conditions and has been shown to enhance the antitumor effects of… (More)
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Highly Cited
1998
Highly Cited
1998
PURPOSE The purpose of the present study is to investigate the strength of association between anemia and overall survival… (More)
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1995
1995
PURPOSE The objectives of this study were to determine the efficacy and toxicity of Etanidazole (ETA), a hypoxic cell sensitizer… (More)
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1992
1992
The therapeutic potential of a variety of bioreductive agents, including misonidazole, RSU-1069, NFVO, mitomycin C, porfiromycin… (More)
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Highly Cited
1986
Highly Cited
1986
We have examined the effects of the benzotriazine di-N-oxide SR-4233 (3-amino-1,2,4-benzotriazine-1,4 dioxide) on a variety of… (More)
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1985
1985
The oxygen dependence of hematoporphyrin derivative (HPD)-induced photoinactivation of Chinese hamster V79 cells was examined… (More)
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1981
1981
We have compared the mouse pharmacokinetics of six analogues of the hypoxic cell sensitizer misonidazole (MISO). The analogues… (More)
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