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Beta-Arrestin-2, human
Known as:
Arrestin Beta-2
, Beta-Arrestin 2
, Beta-Arrestin-2
Beta-arrestin-2 (409 aa, ~46 kDa) is encoded by the human ARRB2 gene. This protein is involved in the modulation of G protein-receptor signaling.
National Institutes of Health
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Related topics
Related topics
11 relations
ARRB2 gene
Cytoplasm
G Protein-Coupled Receptor Signaling
GPCR Signaling Pathway
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Broader (1)
beta-arrestin 2
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Regulation of GPR54 signaling by GRK2 and {beta}-arrestin.
M. Pampillo
,
N. Camuso
,
+6 authors
A. Babwah
Molecular Endocrinology
2009
Corpus ID: 26175978
Kisspeptin and its receptor, GPR54, are major regulators of the hypothalamic-pituitary-gonadal axis as well as regulators of…
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Highly Cited
2006
Highly Cited
2006
Distinct β-Arrestin- and G Protein-dependent Pathways for Parathyroid Hormone Receptor-stimulated ERK1/2 Activation*
D. Gesty‐Palmer
,
Minyong Chen
,
+8 authors
R. Lefkowitz
Journal of Biological Chemistry
2006
Corpus ID: 38715946
Parathyroid hormone (PTH) regulates calcium homeostasis via the type I PTH/PTH-related peptide (PTH/PTHrP) receptor (PTH1R). The…
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Highly Cited
2005
Highly Cited
2005
An Akt/β-Arrestin 2/PP2A Signaling Complex Mediates Dopaminergic Neurotransmission and Behavior
J. Beaulieu
,
T. Sotnikova
,
S. Marion
,
R. Lefkowitz
,
R. Gainetdinov
,
M. Caron
Cell
2005
Corpus ID: 1382881
Highly Cited
2004
Highly Cited
2004
Differential Desensitization, Receptor Phosphorylation, β-Arrestin Recruitment, and ERK1/2 Activation by the Two Endogenous Ligands for the CC Chemokine Receptor 7*
T. Kohout
,
Shelby Nicholas
,
S. Perry
,
Greg J. Reinhart
,
Sachiko Junger
,
R. Struthers
Journal of Biological Chemistry
2004
Corpus ID: 12745065
Many members of the chemokine receptor family of G protein-coupled receptors utilize multiple endogenous ligands. However…
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Highly Cited
2003
Highly Cited
2003
Independent β-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2
Huijun Wei
,
Seungkirl Ahn
,
+4 authors
R. Lefkowitz
Proceedings of the National Academy of Sciences…
2003
Corpus ID: 1882240
Stimulation of a mutant angiotensin type 1A receptor (DRY/AAY) with angiotensin II (Ang II) or of a wild-type receptor with an…
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Highly Cited
2001
Highly Cited
2001
Activation and targeting of extracellular signal-regulated kinases by β-arrestin scaffolds
L. Luttrell
,
F. L. Roudabush
,
+4 authors
R. Lefkowitz
Proceedings of the National Academy of Sciences…
2001
Corpus ID: 205238292
Using both confocal immunofluorescence microscopy and biochemical approaches, we have examined the role of β-arrestins in the…
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Highly Cited
2000
Highly Cited
2000
Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3.
P. McDonald
,
C. Chow
,
+5 authors
R. Lefkowitz
Science
2000
Corpus ID: 38778824
beta-Arrestins, originally discovered in the context of heterotrimeric guanine nucleotide binding protein-coupled receptor (GPCR…
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Highly Cited
2000
Highly Cited
2000
Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence.
L. Bohn
,
R. Gainetdinov
,
F. Lin
,
R. Lefkowitz
,
M. Caron
Nature
2000
Corpus ID: 26096450
Morphine is a powerful pain reliever, but also a potent inducer of tolerance and dependence. The development of opiate tolerance…
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Highly Cited
1994
Highly Cited
1994
Expression of beta-arrestins and beta-adrenergic receptor kinases in the failing human heart.
M. Ungerer
,
G. Parruti
,
+4 authors
M. Lohse
Circulation Research
1994
Corpus ID: 25186510
The beta-adrenergic receptor system of the failing human heart is markedly desensitized. We have recently postulated that this…
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Highly Cited
1993
Highly Cited
1993
Beta-adrenergic receptor kinase-2 and beta-arrestin-2 as mediators of odorant-induced desensitization.
T. Dawson
,
J. Arriza
,
+4 authors
G. Ronnett
Science
1993
Corpus ID: 39958806
beta-Adrenergic receptor kinase (beta ARK) and beta-arrestin function in the homologous or agonist-activated desensitization of G…
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