Beta-Arrestin-2, human

Known as: Arrestin Beta-2, Beta-Arrestin 2, Beta-Arrestin-2 
Beta-arrestin-2 (409 aa, ~46 kDa) is encoded by the human ARRB2 gene. This protein is involved in the modulation of G protein-receptor signaling.
National Institutes of Health

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ARRB2 geneCytoplasmG Protein-Coupled Receptor SignalingGPCR Signaling Pathway
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beta-arrestin 2

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Highly Cited
2008
Highly Cited
2008
Agonist-directed signaling of the serotonin 2A receptor depends on beta-arrestin-2 interactions in vivo.
Visual and auditory hallucinations accompany certain neuropsychiatric disorders, such as schizophrenia, and they also can be… (More)
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Highly Cited
2006
Highly Cited
2006
Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation.
Parathyroid hormone (PTH) regulates calcium homeostasis via the type I PTH/PTH-related peptide (PTH/PTHrP) receptor (PTH1R). The… (More)
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Highly Cited
2005
Highly Cited
2005
An Akt/β-Arrestin 2/PP2A Signaling Complex Mediates Dopaminergic Neurotransmission and Behavior
Dopamine plays an important role in the etiology of schizophrenia, and D2 class dopamine receptors are the best-established… (More)
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Highly Cited
2004
Highly Cited
2004
Differential desensitization, receptor phosphorylation, beta-arrestin recruitment, and ERK1/2 activation by the two endogenous ligands for the CC chemokine receptor 7.
Many members of the chemokine receptor family of G protein-coupled receptors utilize multiple endogenous ligands. However… (More)
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Highly Cited
2003
Highly Cited
2003
Independent beta-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2.
Stimulation of a mutant angiotensin type 1A receptor (DRY/AAY) with angiotensin II (Ang II) or of a wild-type receptor with an… (More)
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Highly Cited
2003
Highly Cited
2003
Beta-arrestin-2 regulates the development of allergic asthma.
Asthma is a chronic inflammatory disorder of the airways that is coordinated by Th2 cells in both human asthmatics and animal… (More)
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Highly Cited
2001
Highly Cited
2001
Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds.
Using both confocal immunofluorescence microscopy and biochemical approaches, we have examined the role of beta-arrestins in the… (More)
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Highly Cited
2000
Highly Cited
2000
Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3.
beta-Arrestins, originally discovered in the context of heterotrimeric guanine nucleotide binding protein-coupled receptor (GPCR… (More)
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Highly Cited
2000
Highly Cited
2000
Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence.
Morphine is a powerful pain reliever, but also a potent inducer of tolerance and dependence. The development of opiate tolerance… (More)
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Highly Cited
1994
Highly Cited
1994
Expression of beta-arrestins and beta-adrenergic receptor kinases in the failing human heart.
The beta-adrenergic receptor system of the failing human heart is markedly desensitized. We have recently postulated that this… (More)
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