Beclin-1

Known as: Beclin1, ATG-6 Protein, Beclin 1 
An autophagy related protein which functions as a core subunit of PHOSPHATIDYLINOSITOL 3-KINASE MULTIPROTEIN COMPLEXES. It mediates the formation of… (More)
National Institutes of Health

Papers overview

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Review
2011
Review
2011
Beclin 1, the mammalian orthologue of yeast Atg6, has a central role in autophagy, a process of programmed cell survival, which… (More)
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Highly Cited
2010
Highly Cited
2010
The mammalian ortholog of yeast Atg6/Vps30, Beclin 1, is an essential autophagy protein that has been linked to diverse… (More)
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Highly Cited
2009
Highly Cited
2009
Autophagy, an evolutionarily conserved process, has functions both in cytoprotective and programmed cell death mechanisms. Beclin… (More)
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Highly Cited
2008
Highly Cited
2008
Autophagy is the principal cellular pathway for degradation of long-lived proteins and organelles and regulates cell fate in… (More)
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Highly Cited
2007
Highly Cited
2007
The anti-apoptotic proteins Bcl-2 and Bcl-X(L) bind and inhibit Beclin-1, an essential mediator of autophagy. Here, we… (More)
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Highly Cited
2007
Highly Cited
2007
Bcl-2 family proteins are key regulators of apoptosis and have recently been shown to modulate autophagy. The tumor suppressor… (More)
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Highly Cited
2005
Highly Cited
2005
Apoptosis and autophagy are both tightly regulated biological processes that play a central role in tissue homeostasis… (More)
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Highly Cited
2003
Highly Cited
2003
Malignant cells often display defects in autophagy, an evolutionarily conserved pathway for degrading long-lived proteins and… (More)
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Highly Cited
2003
Highly Cited
2003
The biochemical properties of beclin 1 suggest a role in two fundamentally important cell biological pathways: autophagy and… (More)
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Highly Cited
1999
Highly Cited
1999
The process of autophagy, or bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway, is important in… (More)
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