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BRD4 Inhibitor PLX51107

Known as: PLX 51107, PLX-51107, PLX51107 
An inhibitor of the bromodomain-containing protein 4 (BRD4), with potential antineoplastic activity. Upon administration, the BRD4 inhibitor PLX51107… 
National Institutes of Health

Related topics

Related topics

1 relation
NCIt Antineoplastic Agent Terminology

Papers overview

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2019
2019
Bromodomain and Extraterminal (BET) Domain Inhibition with PLX51107 and PLX2853 Improves Survival and Decreases Acute GVHD Severity in Murine Models
Introduction: Acute Graft-versus-Host Disease (aGVHD) affects 30-70% of all allogeneic stem cell transplant (alloSCT) recipients… 
2018
2018
Abstract 5852: FGF2 confers resistance to novel BET inhibitors in metastatic uveal melanoma
Uveal melanoma (UM) is the most common intraocular malignancy in adults and frequently metastasizes to the liver. Metastatic UM… 
2018
2018
PLX51107, a promising novel bromodomain and extra-terminal inhibitor in chronic lymphoid leukemia treatment
Historically hematopoietic malignancies were classified as genetic diseases depending on a small number of driver mutations… 
2017
2017
PDTM-15. PLX51107, A NOVEL BROMODOMAIN INHIBITOR, WORKS SYNERGISTICALLY WITH AURORA-A KINASE INHIBITOR MLN8327 IN TREATING MYC-AMPLIFIED MEDULLOBLASTOMA
2016
2016
Abstract 4711: Broad anti-tumor activity of a novel BET bromodomain inhibitor
Inhibitors against the bromodomain and extra terminal domain (BET) family of proteins have been pursued as promising oncology… 
2015
2015
Efficacy and Mechanism of Action of the Novel Bromodomain Inhibitor, PLX51107, in B Cell Malignancies
Background: BRD4 functions as an important epigenetic regulator of transcription of pathways commonly involved in oncogenesis… 
2013
2013
Vemurafenib (PLX4032, Zelboraf®), a BRAF Inhibitor, Modulates ABCB1-, ABCG2-, and ABCC10-Mediated Multidrug Resistance
In this study, we examined the in vitro effects of vemurafenib, a specific inhibitor of V600E mutated BRAF enzyme, on the… 
2011
2011
Inhibition of BRD4 Bromodomains Is a Potent Novel Strategy to Target Apoptosis Resistance in Paediatric ALL
Abstract 77 Despite significant improvements in survival rates for children with B-cell acute lymphoblastic leukaemia (ALL… 
1999
1999
Effects of leukocyte-depleted warm blood cardioplegia on cardiac and endothelial function.
It has been reported that neutrophils and platelets have deleterious effects on myocardium and endothelium during and after… 
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