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BRCC3 gene

Known as: BRCC36, BRCC3, Lys-63-specific deubiquitinase 
This gene plays a role in the deubiquitination of histones.
National Institutes of Health

Related topics

Related topics

5 relations
DeubiquitinationDouble Strand Break RepairHydrolysisProteolysis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Role of deubiquitylase BRCC36 at DNA double-strand breaks
2012
2012
Cell Cycle , Cell Death , and Senescence Degradation of Human RAP 80 is Cell Cycle Regulated by Cdc 20 and Cdh 1 Ubiquitin Ligases
Receptor-associated protein 80 (RAP80) is a component of the BRCA1-A complex that recruits BRCA1 toDNA damage sites in the DNA… 
2011
2011
BRCA1 A-Complex fine tunes repair functions of BRCA1
Germline mutations in BRCA1 increase the risk of breast and ovarian cancer, but the specific pathways driving breast and ovarian… 
2011
2011
Modification of BRCA 1-Associated Breast and Ovarian Cancer Risk by BRCA 1-Interacting Genes
Inherited BRCA1 mutations confer elevated cancer risk. Recent studies have identified genes that encode proteins that interact… 
2010
2010
Mutation screening of the MERIT40 gene encoding a novel BRCA1 and RAP80 interacting protein in breast cancer families
MERIT40 is a recently identified BRCA1 and RAP80 interacting protein that is essential for protein–protein interactions of a… 
2009
2009
K 63-specific deubiquitination by two JAMM / MPN þ complexes : BRISC-associated Brcc 36 and proteasomal Poh 1
An unusual deubiquitinating (DUB) activity exists in HeLa cell extracts that is highly specific for cleaving K63-linked but not… 
2008
2008
BRCA1-Associated Protein BRCC36: A Novel Target for Breast Cancer Therapy
Abstract : Since tumor cells in general are genomically unstable and have defects in DNA damage responses, it has been proposed… 
2006
2006
BRCC36, a Novel Subunit of a BRCA1 E3 Ubiquitin Ligase Complex: Candidates for BRCA3
Abstract : Breast cancer is a genetically heterogeneous disease, and multiple genes remain to be identified among non-BRCA1 and… 
2002
2002
Intron factor VIII gene inversion in a population of Italian hemophilia A patients.
Bagnall and collegues[1][1] report a technique to investigate an inversion that disrupts the factor VIII ( F8 ) gene and that… 
Highly Cited
1996
Highly Cited
1996
Two chimaeric transcription units result from an inversion breaking intron 1 of the factor VIII gene and a region reportedly affected by reciprocal translocations in T-cell leukaemia.
Analysis of mRNA in two haemophilic monozygotic twins offers novel information on the organisation of expressed sequences distal… 
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