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BR96-doxorubicin immunoconjugate

Known as: cBR96-doxorubicin immunoconjugate, cBR96-DOX, DOX-MOAB BR96 
An antibody-drug conjugate composed of the chimeric monoclonal antibody BR96 chemically linked to the cytotoxic drug doxorubicin. The antibody moiety… Expand
National Institutes of Health

Related topics

Related topics

5 relations

Narrower (2)

BMS 182248SGN-15

Broader (2)

DoxorubicinMonoclonal Antibodies
cBR96-doxorubicin immunoconjugate/gemcitabine

Papers overview

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Highly Cited
2008
Highly Cited
2008
Phase I trial of the prostate-specific membrane antigen-directed immunoconjugate MLN2704 in patients with progressive metastatic castration-resistant prostate cancer.
PURPOSE MLN2704 is an immunoconjugate designed to deliver the maytansinoid antimicrotubule agent drug maytansinoid-1 directly to… Expand
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2007
2007
Pharmacokinetics, immunogenicity and safety of bivatuzumab mertansine, a novel CD44v6-targeting immunoconjugate, in patients with squamous cell carcinoma of the head and neck.
The prodrug bivatuzumab mertansine (BIWI 1) is a novel CD44v6-targeting humanized monoclonal antibody coupled to the toxin… Expand
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2002
2002
Time dependence of the activity concentration ratio of red marrow to blood and implications for red marrow dosimetry.
BACKGROUND The method for red marrow dosimetry in radioimmunotherapy, in the absence of specific activity uptake in red marrow… Expand
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2000
2000
Enhanced delivery improves the efficacy of a tumor-specific doxorubicin immunoconjugate in a human brain tumor xenograft model.
OBJECTIVE To evaluate dose intensification with osmotic blood-brain barrier disruption (BBBD) and the potential use of drug… Expand
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Highly Cited
1999
Highly Cited
1999
Randomized phase II study of BR96-doxorubicin conjugate in patients with metastatic breast cancer.
PURPOSE BMS-182248-1 (BR96-doxorubicin immunoconjugate) is a chimeric human/mouse monoclonal antibody linked to approximately… Expand
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1997
1997
Antitumor activity of carcinoma-reactive BR96-doxorubicin conjugate against human carcinomas in athymic mice and rats and syngeneic rat carcinomas in immunocompetent rats.
The internalizing monoclonal antibody BR96 was conjugated to the anticancer drug doxorubicin (DOX) using an acid-labile hydrazone… Expand
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1996
1996
A combinatorial library strategy for the rapid humanization of anticarcinoma BR96 Fab.
We have used a combinatorial mutagenesis strategy to humanize BR96, a monoclonal antibody that binds to the Lewis Y class of… Expand
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1995
1995
Stabilization of Chimeric BR96-Doxorubicin Immunoconjugate
Chimeric BR96-doxorubicin conjugate (BR96-DOX) is an immunoconjugate designed to specifically target and kill certain tumor cells… Expand
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Highly Cited
1993
Highly Cited
1993
Cure of xenografted human carcinomas by BR96-doxorubicin immunoconjugates.
Immunoconjugates (BR96-DOX) were prepared between chimeric monoclonal antibody BR96 and the anticancer drug doxorubicin. The… Expand
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1990
1990
A fluorouridine-anti-CEA immunoconjugate is therapeutically effective in a human colonic cancer xenograft model.
5-fluorouridine (FUR), an antineoplastic agent, was site-specifically conjugated to the carbohydrate moiety of a… Expand
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