Skip to search form
Skip to main content
Skip to account menu
Semantic Scholar
Semantic Scholar's Logo
Search 206,179,282 papers from all fields of science
Search
Sign In
Create Free Account
BR96-doxorubicin immunoconjugate
Known as:
cBR96-doxorubicin immunoconjugate
, cBR96-DOX
, DOX-MOAB BR96
Expand
An antibody-drug conjugate composed of the chimeric monoclonal antibody BR96 chemically linked to the cytotoxic drug doxorubicin. The antibody moiety…
Expand
National Institutes of Health
Create Alert
Alert
Related topics
Related topics
6 relations
Narrower (2)
BMS 182248
SGN-15
Broader (2)
Doxorubicin
Monoclonal Antibodies
NCIt Antineoplastic Agent Terminology
cBR96-doxorubicin immunoconjugate/gemcitabine
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
Phase I trial of the prostate-specific membrane antigen-directed immunoconjugate MLN2704 in patients with progressive metastatic castration-resistant prostate cancer.
M. Galsky
,
M. Eisenberger
,
+6 authors
H. Scher
Journal of clinical oncology : official journal…
2008
Corpus ID: 207018856
PURPOSE MLN2704 is an immunoconjugate designed to deliver the maytansinoid antimicrotubule agent drug maytansinoid-1 directly to…
Expand
Highly Cited
2007
Highly Cited
2007
Pharmacokinetics, immunogenicity and safety of bivatuzumab mertansine, a novel CD44v6-targeting immunoconjugate, in patients with squamous cell carcinoma of the head and neck.
A. Sauter
,
C. Kloft
,
+7 authors
K. Hoermann
International journal of oncology
2007
Corpus ID: 12714208
The prodrug bivatuzumab mertansine (BIWI 1) is a novel CD44v6-targeting humanized monoclonal antibody coupled to the toxin…
Expand
2004
2004
Stabilization of Chimeric BR96-Doxorubicin Immunoconjugate
Nancy Barbour
,
M. Paborji
,
T. C. Alexander
,
W. P. Coppola
,
J. B. Bogardus
Pharmaceutical Research
2004
Corpus ID: 2637121
Chimeric BR96-doxorubicin conjugate (BR96-DOX) is an immunoconjugate designed to specifically target and kill certain tumor cells…
Expand
2001
2001
Selective tumor sensitization to taxanes with the mAb‐drug conjugate cBR96‐doxorubicin
A. Wahl
,
K. L. Donaldson
,
B. Mixan
,
P. Trail
,
C. Siegall
International journal of cancer
2001
Corpus ID: 41464832
The chimeric monoclonal antibody cBR96 conjugated to doxorubicin (cBR96‐Dox) is selectively internalized by a wide variety of…
Expand
Highly Cited
2000
Highly Cited
2000
Enhanced delivery improves the efficacy of a tumor-specific doxorubicin immunoconjugate in a human brain tumor xenograft model.
L. G. Remsen
,
P. Trail
,
I. Hellström
,
K. Hellström
,
E. Neuwelt
Neurosurgery
2000
Corpus ID: 23707405
OBJECTIVE To evaluate dose intensification with osmotic blood-brain barrier disruption (BBBD) and the potential use of drug…
Expand
Highly Cited
1999
Highly Cited
1999
Randomized phase II study of BR96-doxorubicin conjugate in patients with metastatic breast cancer.
A. Tolcher
,
S. Sugarman
,
+7 authors
W. Slichenmyer
Journal of clinical oncology : official journal…
1999
Corpus ID: 33427665
PURPOSE BMS-182248-1 (BR96-doxorubicin immunoconjugate) is a chimeric human/mouse monoclonal antibody linked to approximately…
Expand
Highly Cited
1997
Highly Cited
1997
Antitumor activity of carcinoma-reactive BR96-doxorubicin conjugate against human carcinomas in athymic mice and rats and syngeneic rat carcinomas in immunocompetent rats.
H. Sjögren
,
M. Isaksson
,
D. Willner
,
I. Hellström
,
K. Hellström
,
P. Trail
Cancer research
1997
Corpus ID: 15242509
The internalizing monoclonal antibody BR96 was conjugated to the anticancer drug doxorubicin (DOX) using an acid-labile hydrazone…
Expand
Highly Cited
1996
Highly Cited
1996
A Combinatorial Library Strategy for the Rapid Humanization of Anticarcinoma BR96 Fab*
M. Rosok
,
D. Yelton
,
+8 authors
S. Glaser
The Journal of Biological Chemistry
1996
Corpus ID: 45216980
We have used a combinatorial mutagenesis strategy to humanize BR96, a monoclonal antibody that binds to the Lewis Y class of…
Expand
1995
1995
Analysis of monoclonal antibody chimeric BR96-doxorubicin immunoconjugate by sodium dodecyl sulfate-capillary gel electrophoresis with ultraviolet and laser-induced fluorescence detection.
J. Liu
,
S. Abid
,
M. Lee
Analytical biochemistry
1995
Corpus ID: 22218413
Sodium dodecyl sulfate-capillary gel electrophoresis (SDS-CAGE), the capillary version of SDS-polyacrylamide-based slab gel…
Expand
Highly Cited
1993
Highly Cited
1993
Cure of xenografted human carcinomas by BR96-doxorubicin immunoconjugates.
P. Trail
,
D. Willner
,
+6 authors
K. Hellström
Science
1993
Corpus ID: 13092725
Immunoconjugates (BR96-DOX) were prepared between chimeric monoclonal antibody BR96 and the anticancer drug doxorubicin. The…
Expand
By clicking accept or continuing to use the site, you agree to the terms outlined in our
Privacy Policy
,
Terms of Service
, and
Dataset License
ACCEPT & CONTINUE