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BR96-doxorubicin immunoconjugate

Known as: cBR96-doxorubicin immunoconjugate, cBR96-DOX, DOX-MOAB BR96 
An antibody-drug conjugate composed of the chimeric monoclonal antibody BR96 chemically linked to the cytotoxic drug doxorubicin. The antibody moiety… Expand
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
PURPOSE MLN2704 is an immunoconjugate designed to deliver the maytansinoid antimicrotubule agent drug maytansinoid-1 directly to… Expand
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Highly Cited
2007
Highly Cited
2007
The prodrug bivatuzumab mertansine (BIWI 1) is a novel CD44v6-targeting humanized monoclonal antibody coupled to the toxin… Expand
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2004
2004
Chimeric BR96-doxorubicin conjugate (BR96-DOX) is an immunoconjugate designed to specifically target and kill certain tumor cells… Expand
2001
2001
The chimeric monoclonal antibody cBR96 conjugated to doxorubicin (cBR96‐Dox) is selectively internalized by a wide variety of… Expand
Highly Cited
2000
Highly Cited
2000
OBJECTIVE To evaluate dose intensification with osmotic blood-brain barrier disruption (BBBD) and the potential use of drug… Expand
Highly Cited
1999
Highly Cited
1999
PURPOSE BMS-182248-1 (BR96-doxorubicin immunoconjugate) is a chimeric human/mouse monoclonal antibody linked to approximately… Expand
Highly Cited
1997
Highly Cited
1997
The internalizing monoclonal antibody BR96 was conjugated to the anticancer drug doxorubicin (DOX) using an acid-labile hydrazone… Expand
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Highly Cited
1996
Highly Cited
1996
We have used a combinatorial mutagenesis strategy to humanize BR96, a monoclonal antibody that binds to the Lewis Y class of… Expand
1995
1995
Sodium dodecyl sulfate-capillary gel electrophoresis (SDS-CAGE), the capillary version of SDS-polyacrylamide-based slab gel… Expand
Highly Cited
1993
Highly Cited
1993
Immunoconjugates (BR96-DOX) were prepared between chimeric monoclonal antibody BR96 and the anticancer drug doxorubicin. The… Expand