BKM120

Known as: PI3K Inhibitor BKM120 
 
National Institutes of Health

Papers overview

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Review
2017
Review
2017
The phosphatidylinositol 3-kinase (PI3K) pathway is frequently activated in human cancers. Class I PI3Ks are lipid kinases that… (More)
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Highly Cited
2015
Highly Cited
2015
PURPOSE MAPK and PI3K/AKT/mTOR pathways play important roles in many tumors. In this study, safety, antitumor activity, and… (More)
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Highly Cited
2012
Highly Cited
2012
PURPOSE This phase I dose-escalation study investigated the maximum-tolerated dose (MTD), safety, preliminary activity… (More)
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Highly Cited
2012
Highly Cited
2012
Following the discovery of NVP-BEZ235, our first dual pan-PI3K/mTOR clinical compound, we sought to identify additional… (More)
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Highly Cited
2012
Highly Cited
2012
UNLABELLED PARP inhibitors are active in tumors with defects in DNA homologous recombination (HR) due to BRCA1/2 mutations. The… (More)
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Highly Cited
2012
Highly Cited
2012
PURPOSE The aim of this study was to show preclinical efficacy and clinical development potential of NVP-BKM120, a selective pan… (More)
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Highly Cited
2012
Highly Cited
2012
UNLABELLED There is a need to improve treatments for metastatic breast cancer. Here, we show the activation of the… (More)
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2012
2012
522 Background: New targeted agents against tyrosine kinases expand the standard therapy in oncology. However, tumor resistance… (More)
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Highly Cited
2011
Highly Cited
2011
Phosphoinositide-3-kinases (PI3Ks) are important oncology targets due to the deregulation of this signaling pathway in a wide… (More)
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Highly Cited
2010
Highly Cited
2010
The malignant brain cancer medulloblastoma is characterized by mutations in Hedgehog (Hh) signaling pathway genes, which lead to… (More)
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