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BIIE 0246

Known as: BIIE-0246, BIIE0246, N(2)-((1-(2-(4-(5,11-dihydro-6(6H)-oxodibenz(b,e)azepin-11-yl)-1-piperazinyl)-2-oxoethyl)cyclopentyl)acetyl)-N-(2-(1,2-dihydro-3,5(4H)-dioxo-1,2-diphenyl-3H-1,2,4-triazol-4-yl)ethyl)argininamide 
 
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
Exaggerated GLP-1 and PYY secretion is thought to be a major mechanism in the reduced food intake and body weight after Roux-en-Y… Expand
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Highly Cited
2005
Highly Cited
2005
Glucagon-like peptide-1(7-36NH2) (GLP-1) and peptide YY(3-36NH2) (PYY(3-36NH2)) are cosecreted from the intestine in response to… Expand
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Highly Cited
2005
Highly Cited
2005
The gastrointestinal-derived hormone peptide YY (PYY) is released from intestinal L-cells post-prandially in proportion to… Expand
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Highly Cited
2005
Highly Cited
2005
Systemic injection of peptide YY3‐36 reduces food intake in rodents and humans, although some groups have reported a lack of… Expand
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Highly Cited
2005
Highly Cited
2005
Neuropeptide Y (NPY) potently inhibits glutamate release and seizure activity in rodent hippocampus in vitro and in vivo, but the… Expand
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Highly Cited
2002
Highly Cited
2002
The present study was undertaken to investigate the possible antidepressant-like effects of neuropeptide Y (NPY) in the mouse… Expand
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Review
2000
Review
2000
Neuropeptide Y (NPY), peptide YY (PYY) and pancreatic polypeptide (PP) belong to the NPY hormone family and activate a class of… Expand
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Highly Cited
2000
Highly Cited
2000
BIIE0246, a newly synthesized non‐peptide neuropeptide Y (NPY) Y2 receptor antagonist, was able to compete with high affinity (8… Expand
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Highly Cited
2000
Highly Cited
2000
We have examined the selective neuropeptide Y Y(2) receptor antagonist, (S)-N(2)-[[1-[2-[4-[(R,S)-5,11-dihydro-6(6h)-oxodibenz[b… Expand
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Highly Cited
1999
Highly Cited
1999
The in vitro biological characterisation of the first potent and selective non-peptide neuropeptide Y Y(2) receptor antagonist… Expand
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