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BI 2536

Known as: BI-2536, BI2536 
A small molecule compound with potential antineoplastic activities. BI 2536 binds to and inhibits Polo-like kinase 1 (Plk1), resulting in mitotic… Expand
National Institutes of Health

Papers overview

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2015
2015
A focused library of analogues of the dual PLK1 kinase/BRD4 bromodomain inhibitor BI-2536 was prepared and then analyzed for BRD4… Expand
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Highly Cited
2014
Highly Cited
2014
Members of the bromodomain and extra terminal (BET) family of proteins are essential for the recognition of acetylated lysine… Expand
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Highly Cited
2011
Highly Cited
2011
A nuclear protein target, polo-like kinase 1 (PLK1) was imaged using a biocompatible bioorthogonal ligation between a specific… Expand
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Highly Cited
2010
Highly Cited
2010
Cytokinesis requires a membrane-remodeling and fission event termed abscission that occurs after chromosome segregation, cleavage… Expand
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Highly Cited
2010
Highly Cited
2010
Purpose: This phase I, open-label, dose-escalation study investigated the maximum tolerated dose (MTD) of BI 2536, a small… Expand
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Highly Cited
2010
Highly Cited
2010
In most patients with chronic myeloid leukemia (CML), the disease can be kept under control using the BCR/ABL kinase inhibitor… Expand
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Highly Cited
2009
Highly Cited
2009
Polo-like kinase 1 (Plk1) is a major mitotic regulator overexpressed in many solid tumors. Its role in hematopoietic malignancies… Expand
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Highly Cited
2008
Highly Cited
2008
PURPOSE BI 2536 is a novel, potent, and highly specific inhibitor of polo-like kinase 1 (Plk1), which has an essential role in… Expand
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Highly Cited
2007
Highly Cited
2007
BACKGROUND The mitotic kinases, Cdk1, Aurora A/B, and Polo-like kinase 1 (Plk1) have been characterized extensively to further… Expand
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Highly Cited
2007
Highly Cited
2007
Fine-mapping of the cell-division cycle, notably the identification of mitotic kinase signaling pathways, provides novel… Expand
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