BI 2536

Known as: BI-2536, BI2536 
A small molecule compound with potential antineoplastic activities. BI 2536 binds to and inhibits Polo-like kinase 1 (Plk1), resulting in mitotic… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2006-2018
05101520062018

Papers overview

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2012
2012
Glioblastoma multiforme (GBM) ranks among the deadliest types of cancer and given these new therapies are urgently needed. To… (More)
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2011
2011
Osteosarcoma is the most common primary malignant tumor of bone, which frequently occurs in the second decade of life. Despite… (More)
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2010
2010
PURPOSE This phase I, open-label, dose-escalation study investigated the maximum tolerated dose (MTD) of BI 2536, a small… (More)
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2010
2010
In most patients with chronic myeloid leukemia (CML), the disease can be kept under control using the BCR/ABL kinase inhibitor… (More)
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2010
2010
Cytokinesis requires a membrane-remodeling and fission event termed abscission that occurs after chromosome segregation, cleavage… (More)
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2010
2010
BI 2536 is a new anti-mitotic drug that targets polo-like kinase 1 (Plk1) and is currently under clinical development for cancer… (More)
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2009
2009
Polo-like kinase 1 (Plk1) is a major mitotic regulator overexpressed in many solid tumors. Its role in hematopoietic malignancies… (More)
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Highly Cited
2008
Highly Cited
2008
PURPOSE BI 2536 is a novel, potent, and highly specific inhibitor of polo-like kinase 1 (Plk1), which has an essential role in… (More)
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Highly Cited
2007
Highly Cited
2007
BACKGROUND The mitotic kinases, Cdk1, Aurora A/B, and Polo-like kinase 1 (Plk1) have been characterized extensively to further… (More)
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Highly Cited
2007
Highly Cited
2007
Fine-mapping of the cell-division cycle, notably the identification of mitotic kinase signaling pathways, provides novel… (More)
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