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BGP 15

Known as: BGP-15 
 
National Institutes of Health

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2 relations

Broader (2)

OximesPiperidines

Papers overview

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Highly Cited
2015
Highly Cited
2015
Mitochondrial dysfunction in oocytes of obese mothers: transmission to offspring and reversal by pharmacological endoplasmic reticulum stress inhibitors.
Over-nutrition in females causes altered fetal growth during pregnancy and permanently programs the metabolism of offspring… Expand
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2014
2014
The small-molecule BGP-15 protects against heart failure and atrial fibrillation in mice.
Heart failure (HF) and atrial fibrillation (AF) share common risk factors, frequently coexist and are associated with high… Expand
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Highly Cited
2012
Highly Cited
2012
Hsp72 preserves muscle function and slows progression of severe muscular dystrophy
Duchenne muscular dystrophy (DMD) is a severe and progressive muscle wasting disorder caused by mutations in the dystrophin gene… Expand
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2012
2012
The HSP co-inducer BGP-15 can prevent the metabolic side effects of the atypical antipsychotics
Weight gain and dysfunction of glucose and lipid metabolism are well-known side effects of atypical antipsychotic drugs (AAPD… Expand
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Highly Cited
2011
Highly Cited
2011
Membrane-Lipid Therapy in Operation: The HSP Co-Inducer BGP-15 Activates Stress Signal Transduction Pathways by Remodeling Plasma Membrane Rafts
Aging and pathophysiological conditions are linked to membrane changes which modulate membrane-controlled molecular switches… Expand
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2010
2010
BGP-15 inhibits caspase-independent programmed cell death in acetaminophen-induced liver injury.
It has been recently shown that acute acetaminophen toxicity results in endoplasmic reticulum redox stress and an increase in… Expand
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Highly Cited
2009
Highly Cited
2009
Improvement of insulin sensitivity by a novel drug, BGP-15, in insulin-resistant patients: a proof of concept randomized double-blind clinical trial.
The efficacy and safety of the new drug, BGP-15, were compared with placebo in insulin-resistant patients in a 28-day dose… Expand
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2003
2003
BGP-15, a hydroximic acid derivative, protects against cisplatin- or taxol-induced peripheral neuropathy in rats.
The neuroprotective effect of BGP-15 against peripheral sensory neuropathy was studied in rats that were exposed to short-term… Expand
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2002
2002
BGP-15 - a novel poly(ADP-ribose) polymerase inhibitor - protects against nephrotoxicity of cisplatin without compromising its antitumor activity.
Nephrotoxicity is one of the major dose limiting side effects of cisplatin chemotherapy. The antitumor and toxic effects are… Expand
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2000
2000
BGP-15, a nicotinic amidoxime derivate protecting heart from ischemia reperfusion injury through modulation of poly(ADP-ribose) polymerase.
The protective effect of O-(3-piperidino-2-hydroxy-1-propyl)nicotinic amidoxime (BGP-15) against ischemia-reperfusion-induced… Expand
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