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BGP 15

Known as: BGP-15 
 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

OximesPiperidines

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Heat Shock Proteins and Autophagy Pathways in Neuroprotection: From Molecular Bases to Pharmacological Interventions
Neurodegenerative diseases (NDDs) such as Alzheimer’s disease, Parkinson’s disease and Huntington’s disease (HD), amyotrophic… Expand
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2016
2016
The chaperone co-inducer BGP-15 alleviates ventilation-induced diaphragm dysfunction
BGP-15 reduces ventilation-induced diaphragm dysfunction by improving diaphragm fiber and myosin function and enhancing… Expand
Highly Cited
2014
Highly Cited
2014
The small-molecule BGP-15 protects against heart failure and atrial fibrillation in mice.
Heart failure (HF) and atrial fibrillation (AF) share common risk factors, frequently coexist and are associated with high… Expand
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2012
2012
The HSP co-inducer BGP-15 can prevent the metabolic side effects of the atypical antipsychotics
Weight gain and dysfunction of glucose and lipid metabolism are well-known side effects of atypical antipsychotic drugs (AAPD… Expand
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Highly Cited
2012
Highly Cited
2012
Hsp72 preserves muscle function and slows progression of severe muscular dystrophy
Duchenne muscular dystrophy (DMD) is a severe and progressive muscle wasting disorder caused by mutations in the dystrophin gene… Expand
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Highly Cited
2011
Highly Cited
2011
Membrane-Lipid Therapy in Operation: The HSP Co-Inducer BGP-15 Activates Stress Signal Transduction Pathways by Remodeling Plasma Membrane Rafts
Aging and pathophysiological conditions are linked to membrane changes which modulate membrane-controlled molecular switches… Expand
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Highly Cited
2010
Highly Cited
2010
BGP-15 inhibits caspase-independent programmed cell death in acetaminophen-induced liver injury.
It has been recently shown that acute acetaminophen toxicity results in endoplasmic reticulum redox stress and an increase in… Expand
Highly Cited
2009
Highly Cited
2009
Improvement of insulin sensitivity by a novel drug, BGP-15, in insulin-resistant patients: a proof of concept randomized double-blind clinical trial.
The efficacy and safety of the new drug, BGP-15, were compared with placebo in insulin-resistant patients in a 28-day dose… Expand
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Highly Cited
2002
Highly Cited
2002
BGP-15 - a novel poly(ADP-ribose) polymerase inhibitor - protects against nephrotoxicity of cisplatin without compromising its antitumor activity.
Nephrotoxicity is one of the major dose limiting side effects of cisplatin chemotherapy. The antitumor and toxic effects are… Expand
Highly Cited
2000
Highly Cited
2000
BGP-15, a nicotinic amidoxime derivate protecting heart from ischemia reperfusion injury through modulation of poly(ADP-ribose) polymerase.
The protective effect of O-(3-piperidino-2-hydroxy-1-propyl)nicotinic amidoxime (BGP-15) against ischemia-reperfusion-induced… Expand
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