BGJ398

Known as: pan FGFR Kinase Inhibitor BGJ398 
An orally bioavailable pan inhibitor of human fibroblast growth factor receptors (FGFRs) with potential antiangiogenic and antineoplastic activities… (More)

Topic mentions per year

Topic mentions per year

2011-2017
05101520112017

Papers overview

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2018
2018
Purpose No standard treatment exists for patients with cholangiocarcinoma for whom first-line gemcitabine-based therapy fails… (More)
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2017
2017
Purpose This two-part, first-in-human study was initiated in patients with advanced solid tumors harboring genetic alterations in… (More)
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2017
2017
Activation of FGFR signaling through mutations, amplifications, or fusions involving FGFR1, 2, 3, or 4 is seen in multiple tumors… (More)
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2016
2016
Achondroplasia (ACH) is the most frequent form of dwarfism and is caused by gain-of-function mutations in the fibroblast growth… (More)
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2015
2015
PURPOSE FGFR1 copy-number gain (CNG) occurs in head and neck squamous cell cancers (HNSCC) and is used for patient selection in… (More)
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2014
2014
UNLABELLED Cholangiocarcinoma is an intractable cancer, with limited therapeutic options, in which the molecular mechanisms… (More)
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2013
2013
The recent identification of activating fibroblast growth factor receptor 2 (FGFR2) mutations in endometrial cancer has generated… (More)
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2013
2013
Fibroblast growth factor 23 (FGF23) is a circulating factor secreted by osteocytes that is essential for phosphate homeostasis… (More)
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Highly Cited
2012
Highly Cited
2012
UNLABELLED Patient stratification biomarkers that enable the translation of cancer genetic knowledge into clinical use are… (More)
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Highly Cited
2011
Highly Cited
2011
A novel series of N-aryl-N'-pyrimidin-4-yl ureas has been optimized to afford potent and selective inhibitors of the fibroblast… (More)
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