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BET Inhibitor INCB054329

Known as: INCB054329 
An inhibitor of the Bromodomain and Extra-Terminal (BET) family of bromodomain-containing proteins with potential antineoplastic activity. Upon… Expand
National Institutes of Health

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2019
2019
BACKGROUND Chemotherapy is the treatment of choice for metastatic castration-resistant prostate cancer (mCRPC) nonresponsive to… Expand
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2018
2018
OBJECTIVE Homologous recombination (HR)-proficient ovarian tumors have poorer clinical outcomes and show resistance to poly ADP… Expand
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2018
2018
Purpose: Bromodomain and extraterminal domain (BET) proteins regulate the expression of many cancer-associated genes and pathways… Expand
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2018
2018
Introduction: BET proteins are key epigenetic regulators of transcription whose inhibition may suppress expression of genes that… Expand
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2017
2017
Prostate cancer is a leading cause of cancer death worldwide. Deregulated transcriptional factors and epigenetic effectors… Expand
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2016
2016
Inhibitors of the BET family of Bromodomain proteins have been shown to be growth inhibitory across a spectrum of tumor types due… Expand
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2015
2015
Bromodomains (BD) are protein modules that bind acetylated lysine residues and are components of many epigenetic modifiers and… Expand
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2015
2015
Bromodomain and Extra Terminal (BET) protein inhibitors have emerged as a potentially effective therapeutic option for multiple… Expand
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2015
2015
Multiple myeloma (MM) is a disease of plasma cell transformation. Current therapy for MM is initially effective, but nearly all… Expand
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2015
2015
The Bromodomain and extra-terminal (BET) family of proteins consists of BRD2, BRD3, BRD4 and BRDT. Each BET protein contains two… Expand
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