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Purpose: Bromodomain and extraterminal (BET) proteins are key epigenetic transcriptional regulators, inhibition of which may… Expand BACKGROUND
Chemotherapy is the treatment of choice for metastatic castration-resistant prostate cancer (mCRPC) nonresponsive to… Expand OBJECTIVE
Homologous recombination (HR)-proficient ovarian tumors have poorer clinical outcomes and show resistance to poly ADP… Expand Purpose: Bromodomain and extraterminal domain (BET) proteins regulate the expression of many cancer-associated genes and pathways… Expand Introduction: BET proteins are key epigenetic regulators of transcription whose inhibition may suppress expression of genes that… Expand Prostate cancer is a leading cause of cancer death worldwide. Deregulated transcriptional factors and epigenetic effectors… Expand Inhibitors of the BET family of Bromodomain proteins have been shown to be growth inhibitory across a spectrum of tumor types due… Expand Bromodomains (BD) are protein modules that bind acetylated lysine residues and are components of many epigenetic modifiers and… Expand Bromodomain and Extra Terminal (BET) protein inhibitors have emerged as a potentially effective therapeutic option for multiple… Expand Multiple myeloma (MM) is a disease of plasma cell transformation. Current therapy for MM is initially effective, but nearly all… Expand