BET Bromodomains 2/3/4 Inhibitor MK-8628

Known as: MK-8628 
A synthetic, small molecule inhibitor of the BET (Bromodomain and Extra-Terminal) family of bromodomain-containing proteins 2, 3 and 4 with potential… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2016-2016
024620162016

Papers overview

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2017
2017
Triple-negative breast cancer (TNBC) is an aggressive and heterogeneous subgroup of breast tumors clinically defined by the lack… (More)
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2017
2017
The SCLC combination screen examined a 9-point concentration response of 180 third agents, alone and in combination with… (More)
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2016
2016
BACKGROUND The first-in-class small molecule inhibitor OTX015 (MK-8628) specifically binds to bromodomain motifs BRD2, BRD3, and… (More)
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2016
2016
Bromodomain and extraterminal (BET) bromodomain (BRD) proteins are epigenetic readers that bind to acetylated lysine residues on… (More)
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2016
2016
BACKGROUND Bromodomain and extraterminal (BET) proteins are chromatin readers that preferentially affect the transcription of… (More)
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2016
2016
BACKGROUND AND OBJECTIVES OTX015 (MK-8628) is a novel inhibitor of the bromodomain and extraterminal (BET)-bromodomain (BRD… (More)
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2016
2016
Inhibitors targeting epigenetic control points of oncogenes offer a potential mean of blocking tumor progression in small cell… (More)
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2016
2016
The bromodomain inhibitor OTX015 (MK-8628) has shown anti-lymphoma activity as a single agent in both the preclinical and… (More)
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