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BET Bromodomains 2/3/4 Inhibitor MK-8628

Known as: MK-8628 
A synthetic, small molecule inhibitor of the BET (Bromodomain and Extra-Terminal) family of bromodomain-containing proteins 2, 3 and 4 with potential… Expand
National Institutes of Health

Papers overview

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2019
2019
Medulloblastoma is the most prevalent central nervous system tumor in children. Targeted treatment approaches for patients with… Expand
2019
2019
Bromodomain and extraterminal domain (BET) proteins help direct the differentiation of helper T cell subsets, but their role in… Expand
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2018
2018
As regulators of transcription, epigenetic proteins that interpret post-translational modifications to N-terminal histone tails… Expand
Highly Cited
2017
Highly Cited
2017
Triple-negative breast cancer (TNBC) is an aggressive and heterogeneous subgroup of breast tumors clinically defined by the lack… Expand
2017
2017
Bromodomains (BD) are readers of lysine acetylation marks present in numerous proteins associated with chromatin. Here we… Expand
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Highly Cited
2016
Highly Cited
2016
Bromodomain and extraterminal (BET) bromodomain (BRD) proteins are epigenetic readers that bind to acetylated lysine residues on… Expand
2016
2016
Inhibitors targeting epigenetic control points of oncogenes offer a potential mean of blocking tumor progression in small cell… Expand
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2016
2016
e14123Background: Bromodomains (BRD) bind to acetylated lysine residues on histone tails and are directly involved in remodeling… Expand
2016
2016
The bromodomain inhibitor OTX015 (MK-8628) has shown anti-lymphoma activity as a single agent in both the preclinical and… Expand
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Highly Cited
2015
Highly Cited
2015
Background and ObjectivesOTX015 (MK-8628) is a novel inhibitor of the bromodomain and extraterminal (BET)-bromodomain (BRD… Expand
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