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BET Bromodomains 2/3/4 Inhibitor MK-8628

Known as: MK-8628 
A synthetic, small molecule inhibitor of the BET (Bromodomain and Extra-Terminal) family of bromodomain-containing proteins 2, 3 and 4 with potential… 
National Institutes of Health

Papers overview

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2019
2019
Bromodomain and extraterminal domain (BET) proteins help direct the differentiation of helper T cell subsets, but their role in… 
2018
2018
As regulators of transcription, epigenetic proteins that interpret post-translational modifications to N-terminal histone tails… 
2017
2017
Bromodomains (BD) are readers of lysine acetylation marks present in numerous proteins associated with chromatin. Here we… 
Highly Cited
2016
Highly Cited
2016
Triple-negative breast cancer (TNBC) is an aggressive and heterogeneous subgroup of breast tumors clinically defined by the lack… 
Highly Cited
2016
Highly Cited
2016
Bromodomain and extraterminal (BET) bromodomain (BRD) proteins are epigenetic readers that bind to acetylated lysine residues on… 
Highly Cited
2016
Highly Cited
2016
Background and ObjectivesOTX015 (MK-8628) is a novel inhibitor of the bromodomain and extraterminal (BET)-bromodomain (BRD… 
2016
2016
e14123Background: Bromodomains (BRD) bind to acetylated lysine residues on histone tails and are directly involved in remodeling… 
2016
2016
Inhibitors targeting epigenetic control points of oncogenes offer a potential mean of blocking tumor progression in small cell… 
2016
2016
The bromodomain inhibitor OTX015 (MK-8628) has shown anti-lymphoma activity as a single agent in both the preclinical and…