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BET Bromodomains 2/3/4 Inhibitor MK-8628

Known as: MK-8628 
A synthetic, small molecule inhibitor of the BET (Bromodomain and Extra-Terminal) family of bromodomain-containing proteins 2, 3 and 4 with potential… Expand
National Institutes of Health

Papers overview

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2019
2019
Medulloblastoma is the most prevalent central nervous system tumor in children. Targeted treatment approaches for patients with… Expand
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2018
2018
As regulators of transcription, epigenetic proteins that interpret post-translational modifications to N-terminal histone tails… Expand
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2017
2017
Triple-negative breast cancer (TNBC) is an aggressive and heterogeneous subgroup of breast tumors clinically defined by the lack… Expand
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2017
2017
Bromodomains (BD) are readers of lysine acetylation marks present in numerous proteins associated with chromatin. Here we… Expand
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Highly Cited
2016
Highly Cited
2016
Bromodomain and extraterminal (BET) bromodomain (BRD) proteins are epigenetic readers that bind to acetylated lysine residues on… Expand
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2016
2016
e14123Background: Bromodomains (BRD) bind to acetylated lysine residues on histone tails and are directly involved in remodeling… Expand
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2016
2016
Inhibitors targeting epigenetic control points of oncogenes offer a potential mean of blocking tumor progression in small cell… Expand
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2016
2016
The bromodomain inhibitor OTX015 (MK-8628) has shown anti-lymphoma activity as a single agent in both the preclinical and… Expand
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2015
2015
Background and ObjectivesOTX015 (MK-8628) is a novel inhibitor of the bromodomain and extraterminal (BET)-bromodomain (BRD… Expand
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