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BDA-366

 
National Institutes of Health

Papers overview

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2019
2019
Abstract Apoptosis is a fundamental biological phenomenon, in which anti- or proapoptotic proteins of the Bcl-2 family regulate a… Expand
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2018
2018
In many cancers the equilibrium of pro- versus anti-apoptotic BCL-2 proteins is deregulated. BCL-2 inhibitors like Venetoclax… Expand
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2016
2016
Multiple myeloma (MM) is a heterogeneous plasma cell malignancy and remains incurable. B-cell lymphoma-2 (BCL2) protein… Expand
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2016
2016
Overexpression of the antiapoptotic protein Bcl-2 is considered primarily responsible for the increased apoptosis resistance and… Expand
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Review
2016
Review
2016
Overexpression of B cell lymphoma 2 (Bcl-2) proteins is associated with therapy resistance in various human cancers. Traditional… Expand
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Highly Cited
2015
Highly Cited
2015
The BH4 domain of Bcl2 is required for its antiapoptotic function, thus constituting a promising anticancer target. We identified… Expand
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2015
2015
  • Cancer discovery
  • 2015
  • Corpus ID: 41926154
The small molecule BDA-366 selectively inhibits BCL2, converting it to a cell death inducer. 
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2015
2015
The BH4 domain of Bcl2 is required for its antiapoptotic function, thus constituting a promising anticancer target. We identified… Expand
Is this relevant?