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BDA-366

National Institutes of Health

Papers overview

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2019
2019
Abstract Apoptosis is a fundamental biological phenomenon, in which anti- or proapoptotic proteins of the Bcl-2 family regulate a… 
2018
2018
In many cancers the equilibrium of pro- versus anti-apoptotic BCL-2 proteins is deregulated. BCL-2 inhibitors like Venetoclax… 
Review
2016
Review
2016
2016
2016
Multiple myeloma (MM) is a heterogeneous plasma cell malignancy and remains incurable. B-cell lymphoma-2 (BCL2) protein… 
2016
2016
Overexpression of the antiapoptotic protein Bcl-2 is considered primarily responsible for the increased apoptosis resistance and… 
Highly Cited
2015
Highly Cited
2015
2015
2015
The BH4 domain of Bcl2 is required for its antiapoptotic function, thus constituting a promising anticancer target. We identified… 
2015
2015
  • Cancer discovery
  • 2015
  • Corpus ID: 41926154
The small molecule BDA-366 selectively inhibits BCL2, converting it to a cell death inducer.