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BCAR1 protein, human

Known as: Crk-associated substrate, human, BCAR1 Protein, Breast Cancer Anti-Estrogen Resistance 1 Protein 
Encoded by human BCAR1 Gene, conserved ubiquitous 870-amino acid 116 kD cytoplasmic p130CAS (CAS Family) is an adaptor molecule: Ser-region, NH-SH3… 
National Institutes of Health

Related topics

Related topics

20 relations
Adaptor Signaling Protein GeneBCAR1 geneBreast CarcinomaCarcinoma

Broader (1)

Crk-Associated Substrate Protein

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Exposure to Varying Strain Magnitudes Influences the Conversion of Normal Skin Fibroblasts Into Hypertrophic Scar Cells
AbstractMechanical strain is a key contributor in the pathogenesis of hypertrophic scarring, whose optimal stretch magnitudes to… 
2012
2012
Ezrin and BCAR1/p130Cas mediate breast cancer growth as 3-D spheroids
CAS proteins and Ezrin, Radixin, Moesin (ERM) family members act as intracellular scaffolds and are involved in interactions with… 
2012
2012
Regulation of p130(Cas)/BCAR1 expression in tamoxifen-sensitive and tamoxifen-resistant breast cancer cells by EGR1 and NAB2.
Elevated levels of p130(Cas)/BCAR1 (Crk-associated substrate/breast cancer antiestrogen resistance 1) are found in aggressive… 
Highly Cited
2010
Highly Cited
2010
p130Cas is an essential transducer element in ErbB2 transformation
The ErbB2 oncogene is often overexpressed in breast tumors and associated with poor clinical outcome. p130Cas represents a nodal… 
2008
2008
Essential roles of integrin-mediated signaling for the enhancement of malignant properties of melanomas based on the expression of GD3.
2006
2006
Deregulation of Proteasome Function Induces Abl-mediated Cell Death by Uncoupling p130CAS and c-CrkII*
Cell migration and survival are coordinately regulated through activation of c-Abl (Abl) family tyrosine kinases. Activated Abl… 
Highly Cited
2004
Highly Cited
2004
The Prognostic Value of BCAR1 in Patients with Primary Breast Cancer
Purpose: BCAR1, the human homologue of the rat p130Cas protein, was identified in a functional screen for human breast cancer… 
2004
2004
Cleavage of p130Cas in anoikis
p130Cas is a multifunctional signaling adaptor protein. It integrates and relays signals generated from a variety of… 
Highly Cited
2003
Highly Cited
2003
Role of Crk-Associated Substrate in the Regulation of Vascular Smooth Muscle Contraction
Abstract—A pool of actin monomers is induced to polymerize into actin filaments during contractile stimulation of smooth muscle… 
Review
1997
Review
1997
Tyrosine phosphorylation in the action of neuropeptides and growth factors.
The non-receptor tyrosine kinase p125FAK and the adaptor proteins paxillin and p130CAS are implicated in signal transduction at… 
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