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Summary Metabolic activity is intimately linked to T cell fate and function. Using high-resolution mass spectrometry, we… Expand Elevated serum urate concentrations can cause gout, a prevalent and painful inflammatory arthritis. By combining data from >140… Expand Among mammalian sirtuins, SIRT7 is the only enzyme residing in nucleoli where ribosomal DNA is transcribed. Recent reports… Expand DNA double-stranded breaks present a serious challenge for eukaryotic cells. The inability to repair breaks leads to genomic… Expand A number of nuclear complexes modify chromatin structure and operate as functional units. However, the in vivo role of each… Expand Chromatin states have to be faithfully duplicated during DNA replication to maintain cell identity. It is unclear whether or how… Expand We identified a human multiprotein complex (WINAC) that directly interacts with the vitamin D receptor (VDR) through the Williams… Expand The Williams Syndrome Transcription Factor (WSTF), the product of the WBSCR9 gene, is invariably deleted in the… Expand We previously characterized major components of mitotic chromosomes assembled in Xenopus laevis egg extracts and collectively… Expand Williams syndrome (WS) is a developmental disorder caused by deletion of multiple genes at chromosome 7q11.23. Here, we report… Expand