BAK1 wt Allele

Known as: Cell Death Inhibitor 1 Gene, BAK, BCL2-Antagonist/Killer 1 wt Allele 
Human BAK1 wild-type allele is located in the vicinity of 6p21.3 and is approximately 8 kb in length. This allele, which encodes Bcl-2 homologous… (More)
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
Multidomain pro-apoptotic BAX and BAK, once activated, permeabilize mitochondria to trigger apoptosis, whereas anti-apoptotic BCL… (More)
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Highly Cited
2013
Highly Cited
2013
Proapoptotic B-cell lymphoma 2 (BCL-2) antagonist/killer (BAK) and BCL-2-associated X (BAX) form toxic mitochondrial pores in… (More)
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Highly Cited
2010
Highly Cited
2010
Although the proteins BAX and BAK are required for initiation of apoptosis at the mitochondria, how BAX and BAK are activated… (More)
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Highly Cited
2006
Highly Cited
2006
Endoplasmic reticulum (ER) stress-induced apoptosis has been implicated in the development of multiple diseases. However, the in… (More)
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Highly Cited
2005
Highly Cited
2005
Proapoptotic BCL-2 family members BAX and BAK are required for the initiation of mitochondrial dysfunction during apoptosis and… (More)
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Highly Cited
2004
Highly Cited
2004
Genomic instability is a hallmark of cancer development and progression, and characterizing the stresses that create and the… (More)
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Highly Cited
2002
Highly Cited
2002
The "BH3-only" proteins of the BCL-2 family require "multidomain" proapoptotic members BAX and BAK to release cytochrome c from… (More)
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Highly Cited
2002
Highly Cited
2002
BAX and BAK are essential regulators of proapoptotic signaling, and the disruption of apoptosis is linked to the development of… (More)
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Highly Cited
2001
Highly Cited
2001
BACKGROUND Pancreatic cancer is extremely resistant to the induction of apoptosis by chemotherapies; agents that regulate… (More)
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Highly Cited
1997
Highly Cited
1997
Carriage of the bacterium H. pylori in the human stomach is associated with evidence of increased epithelial cell apoptosis. This… (More)
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