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BAK1 wt Allele

Known as: Cell Death Inhibitor 1 Gene, BAK, BCL2-Antagonist/Killer 1 wt Allele 
Human BAK1 wild-type allele is located in the vicinity of 6p21.3 and is approximately 8 kb in length. This allele, which encodes Bcl-2 homologous… 
National Institutes of Health

Related topics

Related topics

5 relations
6p21.3ApoptosisHomo sapiensPositive Regulation of Apoptosis

Broader (1)

BAK1 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2019
Highly Cited
2019
Direct impact of cisplatin on mitochondria induces ROS production that dictates cell fate of ovarian cancer cells
Patients with high-grade serous ovarian cancer (HGSC) frequently receive platinum-based chemotherapeutics, such as cisplatin… 
Highly Cited
2015
Highly Cited
2015
An Interconnected Hierarchical Model of Cell Death Regulation by the BCL-2 Family
Multidomain pro-apoptotic BAX and BAK, once activated, permeabilize mitochondria to trigger apoptosis, whereas anti-apoptotic BCL… 
Highly Cited
2006
Highly Cited
2006
Endoplasmic Reticulum Stress-induced Apoptosis
Endoplasmic reticulum (ER) stress-induced apoptosis has been implicated in the development of multiple diseases. However, the in… 
Highly Cited
2005
Highly Cited
2005
Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum.
Proapoptotic BCL-2 family members BAX and BAK are required for the initiation of mitochondrial dysfunction during apoptosis and… 
Highly Cited
2004
Highly Cited
2004
Hypoxia and defective apoptosis drive genomic instability and tumorigenesis.
Genomic instability is a hallmark of cancer development and progression, and characterizing the stresses that create and the… 
Highly Cited
2002
Highly Cited
2002
Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics.
Highly Cited
2001
Highly Cited
2001
Chemosensitization of pancreatic cancer by inhibition of the 26S proteasome.
BACKGROUND Pancreatic cancer is extremely resistant to the induction of apoptosis by chemotherapies; agents that regulate… 
Review
2000
Review
2000
Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c
We review data supporting a model in which activated tBID results in an allosteric activation of BAK, inducing its… 
Highly Cited
2000
Highly Cited
2000
Biochemical and Genetic Analysis of the Mitochondrial Response of Yeast to BAX and BCL-XL
ABSTRACT The BCL-2 family includes both proapoptotic (e.g., BAX and BAK) and antiapoptotic (e.g., BCL-2 and BCL-XL) molecules… 
Highly Cited
1999
Highly Cited
1999
Butyrate mediates Caco-2 cell apoptosis via up-regulation of pro-apoptotic BAK and inducing caspase-3 mediated cleavage of poly-(ADP-ribose) polymerase (PARP)
Butyrate exerts potent anti-tumor effects by inhibiting cancer cell growth and inducing apoptosis. However, the molecular… 
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