Skip to search form
Skip to main content
Skip to account menu
Semantic Scholar
Semantic Scholar's Logo
Search 217,797,472 papers from all fields of science
Search
Sign In
Create Free Account
BAK1 wt Allele
Known as:
Cell Death Inhibitor 1 Gene
, BAK
, BCL2-Antagonist/Killer 1 wt Allele
Expand
Human BAK1 wild-type allele is located in the vicinity of 6p21.3 and is approximately 8 kb in length. This allele, which encodes Bcl-2 homologous…
Expand
National Institutes of Health
Create Alert
Alert
Related topics
Related topics
5 relations
6p21.3
Apoptosis
Homo sapiens
Positive Regulation of Apoptosis
Broader (1)
BAK1 gene
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2019
Highly Cited
2019
Direct impact of cisplatin on mitochondria induces ROS production that dictates cell fate of ovarian cancer cells
M. Kleih
,
K. Böpple
,
+5 authors
F. Essmann
Cell Death and Disease
2019
Corpus ID: 207914212
Patients with high-grade serous ovarian cancer (HGSC) frequently receive platinum-based chemotherapeutics, such as cisplatin…
Expand
Highly Cited
2015
Highly Cited
2015
An Interconnected Hierarchical Model of Cell Death Regulation by the BCL-2 Family
Hui-Chen Chen
,
M. Kanai
,
+12 authors
E. Cheng
Nature Cell Biology
2015
Corpus ID: 11885018
Multidomain pro-apoptotic BAX and BAK, once activated, permeabilize mitochondria to trigger apoptosis, whereas anti-apoptotic BCL…
Expand
Highly Cited
2006
Highly Cited
2006
Endoplasmic Reticulum Stress-induced Apoptosis
Jianze Li
,
Brenda Lee
,
Amy S. Lee
Journal of Biological Chemistry
2006
Corpus ID: 12676040
Endoplasmic reticulum (ER) stress-induced apoptosis has been implicated in the development of multiple diseases. However, the in…
Expand
Highly Cited
2005
Highly Cited
2005
Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum.
Scott A Oakes
,
L. Scorrano
,
+4 authors
S. Korsmeyer
Proceedings of the National Academy of Sciences…
2005
Corpus ID: 20095936
Proapoptotic BCL-2 family members BAX and BAK are required for the initiation of mitochondrial dysfunction during apoptosis and…
Expand
Highly Cited
2004
Highly Cited
2004
Hypoxia and defective apoptosis drive genomic instability and tumorigenesis.
D. Nelson
,
Ting-Ting Tan
,
A. Rabson
,
Diana Anderson
,
K. Degenhardt
,
E. White
Genes & Development
2004
Corpus ID: 2455485
Genomic instability is a hallmark of cancer development and progression, and characterizing the stresses that create and the…
Expand
Highly Cited
2002
Highly Cited
2002
Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics.
A. Letai
,
M. Bassik
,
L. Walensky
,
M. Sorcinelli
,
S. Weiler
,
S. Korsmeyer
Cancer Cell
2002
Corpus ID: 22810518
Highly Cited
2001
Highly Cited
2001
Chemosensitization of pancreatic cancer by inhibition of the 26S proteasome.
R. Bold
,
S. Virudachalam
,
D. McConkey
Journal of Surgical Research
2001
Corpus ID: 34151150
BACKGROUND Pancreatic cancer is extremely resistant to the induction of apoptosis by chemotherapies; agents that regulate…
Expand
Review
2000
Review
2000
Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c
S. Korsmeyer
,
M. Wei
,
+4 authors
P. Schlesinger
Cell Death and Differentiation
2000
Corpus ID: 9482252
We review data supporting a model in which activated tBID results in an allosteric activation of BAK, inducing its…
Expand
Highly Cited
2000
Highly Cited
2000
Biochemical and Genetic Analysis of the Mitochondrial Response of Yeast to BAX and BCL-XL
A. Gross
,
K. Pilcher
,
+5 authors
M. Forte
Molecular and Cellular Biology
2000
Corpus ID: 12511914
ABSTRACT The BCL-2 family includes both proapoptotic (e.g., BAX and BAK) and antiapoptotic (e.g., BCL-2 and BCL-XL) molecules…
Expand
Highly Cited
1999
Highly Cited
1999
Butyrate mediates Caco-2 cell apoptosis via up-regulation of pro-apoptotic BAK and inducing caspase-3 mediated cleavage of poly-(ADP-ribose) polymerase (PARP)
F. Ruemmele
,
S. Dionne
,
I. Qureshi
,
D. Sarma
,
E. Levy
,
E. Seidman
Cell Death and Differentiation
1999
Corpus ID: 26734038
Butyrate exerts potent anti-tumor effects by inhibiting cancer cell growth and inducing apoptosis. However, the molecular…
Expand
By clicking accept or continuing to use the site, you agree to the terms outlined in our
Privacy Policy
(opens in a new tab)
,
Terms of Service
(opens in a new tab)
, and
Dataset License
(opens in a new tab)
ACCEPT & CONTINUE