Azurophil granule

Known as: primary granule 
Primary lysosomal granule found in neutrophil granulocytes. Contains a wide range of hydrolytic enzymes and is released into the extracellular fluid… (More)
National Institutes of Health

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Highly Cited
2014
Highly Cited
2014
Immunosenescence is the functional deterioration of the immune system during natural aging. Despite increased susceptibility to… (More)
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Highly Cited
2008
Highly Cited
2008
In acute inflammation, infiltrating polymorphonuclear leukocytes (also known as PMNs) release preformed granule proteins having… (More)
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Highly Cited
2004
Highly Cited
2004
The mouse has become an important model for immunological studies including innate immunity. Creating transgenic mice offers… (More)
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Highly Cited
2004
Highly Cited
2004
The elaboration of dendrites is fundamental to the establishment of neuronal polarity and connectivity, but the mechanisms that… (More)
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Highly Cited
2004
Highly Cited
2004
Neutrophil degranulation is important in many inflammatory disorders, although the intracellular mechanisms underlying this… (More)
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Highly Cited
2001
Highly Cited
2001
Initially identified in high-grade gliomas, mutations in the PTEN tumor-suppressor are also found in many sporadic cancers and a… (More)
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Highly Cited
2001
Highly Cited
2001
Cathelicidins are a family of antimicrobial proteins found in the peroxidase-negative granules of neutrophils. The known biologic… (More)
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1998
1998
Biosynthesis of 3 human granule proteins, myeloperoxidase, defensin and lysozyme, all present in azurophil granules, was… (More)
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Highly Cited
1990
Highly Cited
1990
Anti-neutrophil cytoplasmic autoantibodies (ANCA) are in the circulation of most patients with pauci-immune necrotizing… (More)
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Highly Cited
1989
Highly Cited
1989
The cytokine interleukin 6 (IL-6) has been shown to have multiple biological activities against many cellular targets. The… (More)
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