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Azelastine hydrochloride

Known as: 1(2H)-Phthalazinone, 4-((4-Chlorophenyl)methyl)-2-(hexahydro-1-methyl-1H-azepin-4-yl)-, Monohydrochloride, 4-((4-chlorophenyl)methyl)-2- (hexahydro-1-methyl-1H-azepin-4-yl)-1(2H)- phthalazinone HCl, azelastine hcl 
The hydrochloride salt form of azelastine, a phthalazinone derivative with antihistaminergic activity. Azelastine hydrochloride competes with… Expand
National Institutes of Health

Related topics

Related topics

18 relations

Narrower (4)

A 5610AstelinAsteproDymista
Allergic ConjunctivitisAzelastine hydrochloride 0.206 MG/ACTUAT Metered Dose Nasal Spray [Astepro]Drug AllergyHistamine H1 Receptor Antagonists [MoA]
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Broader (7)

Anti-Allergic AgentsAnti-Inflammatory Agents, Non-SteroidalBronchodilator AgentsHistamine H1 Antagonists
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
MP29-02 (a novel intranasal formulation of azelastine hydrochloride and fluticasone propionate) in the treatment of seasonal allergic rhinitis: a randomized, double-blind, placebo-controlled trial of…
Many patients with allergic rhinitis (AR) have uncontrolled symptoms despite available treatment options. This study was designed… Expand
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2011
2011
Two-week comparison study of olopatadine hydrochloride nasal spray 0.6% versus azelastine hydrochloride nasal spray 0.1% in patients with vasomotor rhinitis.
Olopatadine hydrochloride nasal spray 0.6% (OLO) and azelastine nasal spray 137 micrograms (AZE) are effective in treating… Expand
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Highly Cited
2010
Highly Cited
2010
Double-blind, placebo-controlled study of azelastine and fluticasone in a single nasal spray delivery device.
BACKGROUND A proof-of-concept study suggested that combination therapy with commercial azelastine hydrochloride nasal spray and… Expand
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2008
2008
Combination therapy with azelastine hydrochloride nasal spray and fluticasone propionate nasal spray in the treatment of patients with seasonal allergic rhinitis.
BACKGROUND To our knowledge, there are no published studies that evaluated the efficacy of azelastine hydrochloride nasal spray… Expand
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2002
2002
A study of intranasal distribution of azelastine hydrochloride aqueous nasal spray with different spray techniques.
Topical aqueous nasal sprays are widely used in treating patients with a variety of nasal diseases. Previous studies have… Expand
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Highly Cited
2001
Highly Cited
2001
Efficacy of azelastine nasal spray in the treatment of vasomotor (perennial nonallergic) rhinitis.
BACKGROUND Azelastine hydrochloride is an antihistamine with anti-inflammatory properties that is available in the United States… Expand
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2001
2001
Evaluation of the efficacy of olopatadine hydrochloride 0.1% ophthalmic solution and azelastine hydrochloride 0.05% ophthalmic solution in the conjunctival allergen challenge model.
BACKGROUND Olopatadine hydrochloride 0.1% ophthalmic solution and azelastine hydrochlofide 0.05% ophthalmic solution are 2… Expand
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1999
1999
Azelastine N-demethylation by cytochrome P-450 (CYP)3A4, CYP2D6, and CYP1A2 in human liver microsomes: evaluation of approach to predict the contribution of multiple CYPs.
Azelastine, an antiallergy and antiasthmatic drug, has been reported to be mainly N-demethylated to desmethylazelastine in humans… Expand
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1997
1997
Suppression by azelastine hydrochloride of NF-kappa B activation involved in generation of cytokines and nitric oxide.
The influence of the anti-allergy agent azelastine hydrochloride (Azeptin) on NF-kappa B activation associated with the… Expand
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1994
1994
Prophylaxis of oral mucositis associated with chemoradiotherapy for oral carcinoma by Azelastine hydrochloride (Azelastine) with other antioxidants.
BACKGROUND One of the dose-limiting adverse effects of chemoradiotherapy is mucositis, especially oral mucositis. Prophylaxis of… Expand
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