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Azauridine
Known as:
ribo-azauracil
, 3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine riboside
, 6-Azauracil 1-riboside
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A synthetic triazine analogue of uridine with antimetabolite activity. 6-azauridine inhibits de novo pyrimidine synthesis and DNA synthesis and is…
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National Institutes of Health
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Related topics
Related topics
14 relations
Narrower (4)
2-thio-6-azauridine
3-deaza-6-azauridine
6-azauridine 5'-triphosphate
azaribine
Broader (3)
Antimetabolites, Antineoplastic
Dermatologic Agents
Nucleoside Analogs
In Blood
agonists
analogs & derivatives
antagonists & inhibitors
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
1983
1983
Synthesis and biological evaluation of 2-fluoro-8-azaadenosine and related compounds.
J. Montgomery
,
A. Shortnacy
,
J. Secrist
Journal of Medicinal Chemistry
1983
Corpus ID: 35452323
The synthesis of 2-fluoro-8-azaadenosine (6e) and 2-amino-8-azaadenosine (6d) is described. Condensation of 9H-2,6-bis(methylthio…
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1977
1977
Effects of 6-azauridine on nucleotides, orotic acid, and orotidine in L5178Y mouse lymphoma cells in vitro.
C. M. Janeway
,
S. Cha
Cancer Research
1977
Corpus ID: 17260946
Murine lymphoma L5178Y cells in culture were exposed to 5 µm 6-azauridine (6-aza-UR) for up to 8 hr. The nucleotides in the acid…
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Highly Cited
1976
Highly Cited
1976
Nucleosides. 100. General synthesis of pyrimidine C-5 cucleosides related to pseudouridine. Synthesis of 5-(beta-D-ribofuranosyl) isocytosine (pseudoisocytidine),5-(beta-D-ribofuranosyl)-2-thiouracil…
C. K. Chu
,
I. Wempen
,
K. Watanabe
,
J. Fox
Journal of Organic Chemistry
1976
Corpus ID: 46279185
1976
1976
Effects of cytosine arabinoside, adenine arabinoside, and 6-azauridine on rabies virus in vitro and in vivo.
M. Harmon
,
B. Janis
Journal of Infectious Diseases
1976
Corpus ID: 24982694
The antiviral agents cytosine arabinoside, adenine arabinoside, and 6-azauridine were shown to inhibit the replication of rabies…
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1975
1975
Effect of l-β-D-Ribofuranosyl-l,2,4-Triazole-3-Carboxamide (Ribavirin) on Friend Leukemia Virus Infections in Mice
R. Sidwell
,
L. B. Allen
,
J. Huffman
,
J. T. Witkowski
,
L. Simon
1975
Corpus ID: 57339608
Summary Ribavirin, when administered intraperitoneally to mice infected with Friend leukemia virus, significantly inhibited…
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Highly Cited
1972
Highly Cited
1972
Azapurine nucleosides. 1. Synthesis and antitumor activity of certain 3- -D-ribofuranosyl- and 2'-deoxy-D-ribofuranosyl-v-triazolo(4,5-d)pyrimidines.
W. Hutzenlaub
,
R. Tolman
,
R. K. Robins
Journal of Medicinal Chemistry
1972
Corpus ID: 37498000
Highly Cited
1966
Highly Cited
1966
Beneficial effects of triacetyl azauridine in psoriasis and mycosis fungoides.
P. Calabresi
,
R. W. Turner
Annals of Internal Medicine
1966
Corpus ID: 38553168
Excerpt The usefulness of antimetabolites capable of inhibiting nucleic acid biosynthesis has been generally limited by their…
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1963
1963
Chromosome Changes Caused by 6-Azauridine During Treatment of Acute Myeloblastic Leukaemia
M. Elves
,
A. S. Buttoo
,
M. Israél̀s
,
J. Wilkison
British medical journal
1963
Corpus ID: 40303122
Changes produced in chromosomes in human tissue cultures have been described following the use of x-irradiation and radio-drugs…
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Highly Cited
1962
Highly Cited
1962
Summary of current information on 6-azauridine.
R. Handschumacher
,
P. Calabresi
,
A. D. Welch
,
V. Bono
,
H. Fallon
,
E. Frei
Cancer chemotherapy reports
1962
Corpus ID: 28459900
1961
1961
Alterations in human pyrimidine metabolism as a result of therapy with 6-azauridine.
S. Cardoso
,
P. Calabresi
,
R. Handschumacher
Cancer Research
1961
Corpus ID: 34635969
Summary Biochemical procedures are described which have been found useful in the study of normal pyrimidine metabolism as…
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