Autologous CD133-Positive BTSC mRNA-Pulsed Autologous Dendritic Cell Vaccine
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Failure to eradicate cancer stem cells (CSC) during primary therapy may lead to cancer recurrence. We recently reported that… Expand BackgroundCD133-positive cells in hepatocellular carcinoma (HCC) exhibit cancer stem cell (CSC)-like properties as well as… Expand OBJECTIVE Defects in the apoptotic machinery and augmented survival signals contribute to drug resistance in glioblastoma (GBM… Expand There is increasing evidence supporting the cancer stem cell (CSC) hypothesis, which suggests that a population of tumor cells… Expand Purpose Due to their minimal-invasive yet potentially current character circulating tumor cells (CTC) might be useful as a… Expand Glioblastoma multiforme (GBM) is the most common primary brain tumor, with a median survival of only 15 months. A subpopulation… Expand In addition to intrinsic regulatory mechanisms, brain tumor stemlike cells (BTSCs), a small subpopulation of malignant glial… Expand Hypoxia contributes to the progression of a variety of cancers by activating adaptive transcriptional programs that promote cell… Expand BackgroundCD133 was detected in several types of cancers including hepatocellular carcinoma (HCC), which raised the possibility… Expand The presence of a CD133+/nestin+ population in brain tumors suggests that a normal neural stem cell may be the cell of origin for… Expand